Servei de Psiquiatria i Salut Mental, Hospital d'Igualada (Consorci Sanitari de l'Anoia), Igualada, Barcelona 08700, Spain; Unitat de Psicologia Mèdica, Departament de Psiquiatria i Medicina Legal & Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute - IDIBELL], L'Hospitalet de Llobregat, Barcelona 08097, Spain.
Biol Psychol. 2013 Oct;94(2):388-96. doi: 10.1016/j.biopsycho.2013.08.002. Epub 2013 Aug 19.
Borderline Personality Disorder (BPD) patients present profound disturbances in affect regulation and impulse control which could reflect a dysfunction in reward-related processes. The current study investigated these processes in a sample of 18 BPD patients and 18 matched healthy controls, using an event-related brain potentials methodology. Results revealed a reduction in the amplitude of the Feedback-Related Negativity of BPD patients, which is a neurophysiological index of the impact of negative feedback in reward-related tasks. This reduction, in the effect of negative feedback in BPD patients, was accompanied by a different behavioral pattern of risk choice compared to healthy participants. These findings confirm a dysfunctional reward system in BDP patients, which might compromise their capacity to build positive expectations of future rewards and decision making.
边缘型人格障碍（BPD）患者在情绪调节和冲动控制方面存在明显障碍，这可能反映了与奖励相关的过程出现了功能障碍。本研究使用事件相关电位方法，在 18 名 BPD 患者和 18 名匹配的健康对照组中研究了这些过程。结果显示，BPD 患者的反馈相关负波振幅降低，这是奖励相关任务中负反馈影响的神经生理指标。与健康参与者相比，BPD 患者的这种负反馈效应降低，同时伴随着风险选择的行为模式不同。这些发现证实了 BDP 患者的奖励系统功能障碍，这可能会影响他们对未来奖励的积极期望和决策能力。
