苯乙烯致接触工人听力损失、神经行为功能及神经递质改变的研究
Ethylbenzene-induced hearing loss, neurobehavioral function, and neurotransmitter alterations in petrochemical workers.
机构信息
Tianjin Centers for Disease Control and Prevention, China.
出版信息
J Occup Environ Med. 2013 Sep;55(9):1001-6. doi: 10.1097/JOM.0b013e31829f3142.
OBJECTIVE
To estimate hearing loss, neurobehavioral function, and neurotransmitter alteration induced by ethylbenzene in petrochemical workers.
METHODS
From two petrochemical plants, 246 and 307 workers exposed to both ethylbenzene and noise were recruited-290 workers exposed to noise only from a power station plant and 327 office personnel as control group, respectively. Hearing and neurobehavioral functions were evaluated. Serum neurotransmitters were also determined.
RESULTS
The prevalence of hearing loss was much higher in petrochemical groups than that in power station and control groups (P < 0.05). Compared with the control group, scores of neurobehavioral function reflecting learning and memory were decreased in petrochemical workers (P < 0.05), as well as acetylcholinesterase activity. Negative correlation was shown between neurobehavioral function and acetylcholinesterase.
CONCLUSIONS
Ethylbenzene exposure might be associated with hearing loss, neurobehavioral function impairment, and imbalance of neurotransmitters.
目的
评估石化工人接触乙基苯后听力损失、神经行为功能和神经递质改变的情况。
方法
从两个石化工厂中，分别招募了 246 名和 307 名接触乙基苯和噪声的工人、290 名仅接触来自电站噪声的工人以及 327 名办公室人员作为对照组。评估听力和神经行为功能，并测定血清神经递质。
结果
与电站组和对照组相比，石化组的听力损失发生率明显更高（P<0.05）。与对照组相比，石化工人的学习和记忆神经行为功能评分下降（P<0.05），同时乙酰胆碱酯酶活性也降低。神经行为功能与乙酰胆碱酯酶之间呈负相关。
结论
乙基苯暴露可能与听力损失、神经行为功能损伤以及神经递质失衡有关。
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