Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Eur Neurol. 2013;70(3-4):210-7. doi: 10.1159/000346638. Epub 2013 Aug 22.
The purpose of the present study was to measure phase values (PVs) and fractional anisotropy (FA) of cerebral microbleeds (CMBs) using phase and FA map, and to investigate the potential relationship between PVs and FAs in CMBs in vivo.
We retrospectively analyzed 30 patients with CMBs using enhanced T2*-weighted angiography and diffusion tensor imaging. The PVs and FAs of CMBs were measured and documented, and the mean FAs were compared between CMBs and the corresponding normal brain tissue. The mean PVs were correlated with FAs in CMBs in seven different brain regions.
A total of 106 CMBs were defined, and the mean FA of the CMBs in white matter, EC/IC/CR, thalamus, and cerebellum were significantly lower than that of normal brain tissue in the control group (p<0.05). Positive correlations were observed between the PV and FA of CMBs in white matter, external capsule, internal capsule and corona radiata (r=0.70, 0.38).
Enhanced T2*-weighted angiography and diffusion tensor imaging sequence may be useful neuroimaging sequences that could reflect the severity of damage of white matter by measuring the FA of CMBs and provide useful reference data for the quantitative assessment of CMBs.
本研究旨在通过相位和 FA 图测量脑微出血（CMB）的相位值（PVs）和各向异性分数（FA），并探讨体内 CMBs 的 PVs 与 FA 之间的潜在关系。
我们回顾性分析了 30 例 CMBs 患者的增强 T2*-加权血管造影和弥散张量成像资料。测量并记录了 CMBs 的 PVs 和 FA，并比较了 CMBs 与对照组正常脑组织之间的平均 FA 值。在 7 个不同脑区，将 CMBs 的平均 PV 值与 FA 值进行相关性分析。
共定义了 106 个 CMBs，与对照组正常脑组织相比，CMBs 在白质、外囊、内囊和放射冠中的 FA 值明显降低（p<0.05）。在白质、外囊、内囊和放射冠中，CMBs 的 PV 与 FA 值之间存在正相关关系（r=0.70，0.38）。
增强 T2*-加权血管造影和弥散张量成像序列可能是有用的神经影像学序列，通过测量 CMBs 的 FA 值，可以反映白质损伤的严重程度，并为 CMBs 的定量评估提供有用的参考数据。
