Lima Leonardo Santos, Silvério Matheus de Oliveira, Swerts Mário Sérgio Oliveira, Aquino Sibele Nascimento de, Martelli Daniella Reis Barbosa, Martelli-Júnior Hercílio
Health Science Program, State University of Montes Claros, Montes Claros, MG, Brazil.
Braz Dent J. 2013;24(3):200-3. doi: 10.1590/0103-6440201302191.
Congenital malformations and cancer may share common etiological factors and the association between nonsyndromic cleft lip and/or palate (NSCL/P) and cancers has been observed in different studies. The objective of this study was to evaluate the frequency of cancer in relatives of patients with NSCL/P. This investigation was a cross-sectional, case-controlled study, evaluating 358 patients with NSCL/P treated at a Referral Center for craniofacial deformities (case group) and 358 patients without craniofacial alterations (control group). Information concerning the gender, age and family history of cancer in first-degree relatives for both groups was obtained. The frequency of cancer was 6.4% (n=46) in the studied population, with 18 subjects in the case group (5%) and 28 (7.8%) in control. In both groups, the most frequently reported cases were those of breast, colorectal, stomach, prostate and uterus cancers, but there was no association between the two groups. There was no association with a family history of cancer among the first-degree relatives (odds ratio=0.62; 95% IC: 0.34 to 1.15), neither when the analysis was made by type of cancer. In conclusion, both epidemiological and genetic studies have suggested common etiological factors for NSCL/P and cancer. However, in this population-based study, no association between cancer and NSCL/P could be confirmed.
先天性畸形和癌症可能有共同的病因，并且在不同研究中已观察到非综合征性唇裂和/或腭裂（NSCL/P）与癌症之间的关联。本研究的目的是评估NSCL/P患者亲属中癌症的发生率。这项调查是一项横断面病例对照研究，评估了在一家颅面畸形转诊中心接受治疗的358例NSCL/P患者（病例组）和358例无颅面改变的患者（对照组）。获取了两组患者一级亲属的性别、年龄和癌症家族史信息。研究人群中癌症发生率为6.4%（n = 46），病例组有18例（5%），对照组有28例（7.8%）。两组中报告最多的病例均为乳腺癌、结直肠癌、胃癌、前列腺癌和子宫癌，但两组之间无关联。一级亲属的癌症家族史与癌症无关联（优势比 = 0.62；95%置信区间：0.34至1.15），按癌症类型分析时也无关联。总之，流行病学和遗传学研究均提示NSCL/P和癌症有共同的病因。然而，在这项基于人群的研究中，无法证实癌症与NSCL/P之间存在关联。
