Gonçalves Eduardo, Martelli Daniella Reis Barbosa, Coletta Ricardo Della, Vieira Alexandre Rezende, Caldeira Antônio Prates, Martelli Hercílio
Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
Department of Oral Diagnosis, School of Dentistry, Universidade Estadual de Campinas, Piracicaba, SP, Brazil.
Braz Oral Res. 2014;28:1-3. doi: 10.1590/1807-3107bor-2014.vol28.0056. Epub 2014 Oct 17.
The aim of this study was to determine the frequency of leukemia in parents of patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P). This case-control study evaluated first-degree family members of 358 patients with NSCL/P and 1,432 subjects without craniofacial alterations or syndromes. Statistical analysis was carried out using Fisher's test. From the 358 subjects with NSCL/P, 3 first-degree parents had history of leukemia, while 2 out of 1,432 subjects from the unaffected group had a family history of leukemia. The frequency of positive family history of leukemia was not significantly increased in first-degree relatives of patients with NSCL/P.
本研究的目的是确定非综合征性唇裂和/或腭裂（NSCL/P）患者父母中白血病的发病率。这项病例对照研究评估了358例NSCL/P患者的一级家庭成员以及1432名无颅面畸形或综合征的受试者。采用Fisher检验进行统计分析。在358例NSCL/P患者中，有3名一级亲属有白血病病史，而在1432名未受影响组的受试者中，有2名有白血病家族史。NSCL/P患者的一级亲属中白血病家族史阳性的频率没有显著增加。
