Cardoso E-F, Martelli D-R-B, Machado R-A, Coletta R-D, de Souza J-D, Barbosa F-T, de Figueiredo M-F-L, Coelho L-G-V, Martelli-Júnior H
State University of Montes Claros, School of Medicine, Bario street, 258, Edgar Pereira, Montes Claros, Minas Gerais, Brazil, Zip Code: 39400-167,
Med Oral Patol Oral Cir Bucal. 2018 Jan 1;23(1):e44-e48. doi: 10.4317/medoral.22132.
To determine the frequency of nonsyndromic cleft lip and/or palate (NSCL/P) in first-degree relatives and to analyze the prevalence of tooth agenesis in patients with gastric cancer.
This cross-sectional, observational, case-control study included 798 patients attended at hospital Santa Casa in Montes Claros, Minas Gerais and Alfa Institute of Gastroenterology of the Federal University of the Minas Gerais. Information on basic demographic data and tooth agenesis of both groups and their family history of NSCL/P in first-degree relatives were evaluated. The collected information was stored in a database and analyzed using statistical program SPSS version 21.0 and the values with p<0.05 were considered statistically significant.
Of the 798 patients, 113 (14.16%) consisted of the case group and 685 of the control group (85.84%). Non-Caucasian males were the most affected, although no differences among the groups were detected. Of all participants (n=798), 66 (8.27%) presented tooth agenesis and 25 (3.13%) presented oral cleft in first degree relative.
Our results no found increase in the frequency of tooth agenesis in patients with gastric cancer and in the frequency of NSCL/P in the first-degree relatives of patients with gastric cancer.
确定一级亲属中非综合征性唇裂和/或腭裂（NSCL/P）的发生率，并分析胃癌患者中牙齿缺失的患病率。
这项横断面、观察性病例对照研究纳入了在米纳斯吉拉斯州蒙特斯克拉罗斯的圣卡莎医院和米纳斯吉拉斯联邦大学阿尔法胃肠病学研究所就诊的798例患者。评估了两组患者的基本人口统计学数据、牙齿缺失情况以及他们一级亲属中NSCL/P的家族史。收集到的信息存储在数据库中，并使用统计软件SPSS 21.0进行分析，p<0.05的值被认为具有统计学意义。
798例患者中，113例（14.16%）为病例组，685例（85.84%）为对照组。非白种男性受影响最大，尽管各组之间未检测到差异。在所有参与者（n = 798）中，66例（8.27%）存在牙齿缺失，25例（3.13%）的一级亲属存在口腔裂隙。
我们的结果未发现胃癌患者牙齿缺失的发生率以及胃癌患者一级亲属中NSCL/P的发生率增加。
