• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

梓醇通过调控 Bax/Bcl-2 表达并激活 caspase-3 通路诱导人胃癌 BGC-823 细胞凋亡。

Ziyuglycoside II-induced apoptosis in human gastric carcinoma BGC-823 cells by regulating Bax/Bcl-2 expression and activating caspase-3 pathway.

机构信息

Affiliated Hangzhou Hospital, Department of General Surgery, Nanjing Medical University, Hangzhou, China.

出版信息

Braz J Med Biol Res. 2013 Aug;46(8):670-5. doi: 10.1590/1414-431X20133050. Epub 2013 Aug 13.

DOI:10.1590/1414-431X20133050
PMID:23969976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3854423/
Abstract

Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties. We report here on the anticancer effect of ziyuglycoside II on human gastric carcinoma BGC-823 cells. We investigated the effects of ziyuglycoside II on cell growth, cell cycle, and cell apoptosis of this cell line. Our results revealed that ziyuglycoside II could inhibit the proliferation of BGC-823 cells by inducing apoptosis but not cell cycle arrest, which was associated with regulation of Bax/Bcl-2 expression, and activation of the caspase-3 pathway. Our study is the first to report the antitumor potential of ziyuglycoside II in BGC-823 gastric cancer cells. Ziyuglycoside II may become a potential therapeutic agent against gastric cancer in the future.

摘要

紫珠苷 II 是地榆的一种活性化合物，具有抗炎、抗氧化、抗菌和内稳态特性。我们在这里报告了紫珠苷 II 对人胃癌 BGC-823 细胞的抗癌作用。我们研究了紫珠苷 II 对该细胞系细胞生长、细胞周期和细胞凋亡的影响。结果表明，紫珠苷 II 通过诱导细胞凋亡而不是细胞周期阻滞来抑制 BGC-823 细胞的增殖，这与 Bax/Bcl-2 表达的调节和 caspase-3 途径的激活有关。我们的研究首次报道了紫珠苷 II 在 BGC-823 胃癌细胞中的抗肿瘤潜力。紫珠苷 II 将来可能成为治疗胃癌的一种潜在药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/c9258287114a/1414-431X-bjmbr-46-08-0670-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/5e3f7288f4a3/1414-431X-bjmbr-46-08-0670-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/22d9169e5292/1414-431X-bjmbr-46-08-0670-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/9c312445c101/1414-431X-bjmbr-46-08-0670-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/94528d312003/1414-431X-bjmbr-46-08-0670-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/433747af299c/1414-431X-bjmbr-46-08-0670-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/c9258287114a/1414-431X-bjmbr-46-08-0670-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/5e3f7288f4a3/1414-431X-bjmbr-46-08-0670-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/22d9169e5292/1414-431X-bjmbr-46-08-0670-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/9c312445c101/1414-431X-bjmbr-46-08-0670-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/94528d312003/1414-431X-bjmbr-46-08-0670-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/433747af299c/1414-431X-bjmbr-46-08-0670-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eec/3854423/c9258287114a/1414-431X-bjmbr-46-08-0670-gf06.jpg

相似文献

1
Ziyuglycoside II-induced apoptosis in human gastric carcinoma BGC-823 cells by regulating Bax/Bcl-2 expression and activating caspase-3 pathway.梓醇通过调控 Bax/Bcl-2 表达并激活 caspase-3 通路诱导人胃癌 BGC-823 细胞凋亡。
Braz J Med Biol Res. 2013 Aug;46(8):670-5. doi: 10.1590/1414-431X20133050. Epub 2013 Aug 13.
2
[Study on functions and mechanism of curcumin in inducing gastric carcinoma BGC apoptosis].姜黄素诱导胃癌BGC细胞凋亡的作用及机制研究
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov;27(11):1227-30.
3
Ziyuglycoside II inhibits the growth of human breast carcinoma MDA-MB-435 cells via cell cycle arrest and induction of apoptosis through the mitochondria dependent pathway.梓醇苷 II 通过线粒体依赖性途径诱导细胞周期停滞和细胞凋亡抑制人乳腺癌 MDA-MB-435 细胞的生长。
Int J Mol Sci. 2013 Sep 3;14(9):18041-55. doi: 10.3390/ijms140918041.
4
Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells.梓醇苷 II 通过激活 ROS/JNK 通路诱导人乳腺癌细胞周期停滞和凋亡。
Toxicol Lett. 2014 May 16;227(1):65-73. doi: 10.1016/j.toxlet.2014.03.015. Epub 2014 Mar 28.
5
Ziyuglycoside II induces caspases-dependent and caspases-independent apoptosis in human colon cancer cells.梓醇苷 II 诱导人结肠癌细胞发生 caspase 依赖性和 caspase 非依赖性凋亡。
Toxicol In Vitro. 2019 Sep;59:255-262. doi: 10.1016/j.tiv.2019.04.028. Epub 2019 Apr 25.
6
Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis.紫裕苷I通过诱导p53介导的G2/M期细胞周期阻滞和内源性/外源性凋亡来抑制MDA-MB-231乳腺癌细胞的增殖。
Int J Mol Sci. 2016 Nov 22;17(11):1903. doi: 10.3390/ijms17111903.
7
Daidzein induced apoptosis via down-regulation of Bcl-2/Bax and triggering of the mitochondrial pathway in BGC-823 cells.大豆苷元通过下调 BGC-823 细胞中 Bcl-2/Bax 并触发线粒体途径诱导细胞凋亡。
Cell Biochem Biophys. 2013 Mar;65(2):197-202. doi: 10.1007/s12013-012-9418-2.
8
Paris saponin I induces apoptosis via increasing the Bax/Bcl-2 ratio and caspase-3 expression in gefitinib-resistant non-small cell lung cancer in vitro and in vivo.巴黎皂苷I通过在体外和体内增加吉非替尼耐药的非小细胞肺癌中Bax/Bcl-2比值和半胱天冬酶-3表达来诱导细胞凋亡。
Mol Med Rep. 2014 Jun;9(6):2265-72. doi: 10.3892/mmr.2014.2108. Epub 2014 Apr 2.
9
Antiangiogenic Effects of Ziyuglycoside II, a Major Active Compound of Sanguisorba officinalis L.地榆主要活性成分地榆糖苷II的抗血管生成作用
Phytother Res. 2017 Sep;31(9):1449-1456. doi: 10.1002/ptr.5874. Epub 2017 Jul 18.
10
Anti-proliferative and apoptotic effects of S1, a tetrandrine derivative, in human gastric cancer BGC-823 cells.S1，一种汉防己甲素衍生物，对人胃癌 BGC-823 细胞的抗增殖和促凋亡作用。
Chin J Nat Med. 2016 Jul;14(7):527-33. doi: 10.1016/S1875-5364(16)30062-0.

引用本文的文献

1
L. ethanolic extracts and essential oil - chemical composition, antioxidant potential, antibacterial activity, and skin permeation study.L.乙醇提取物和精油——化学成分、抗氧化潜力、抗菌活性及皮肤渗透研究。
Front Pharmacol. 2024 Sep 2;15:1390551. doi: 10.3389/fphar.2024.1390551. eCollection 2024.
2
Phytochemical Analysis and Understanding the Antioxidant and Anticancer Properties of Methanol Extract from : In Vitro and In Vivo Studies.植物化学成分分析及甲醇提取物抗氧化和抗癌特性的理解：体外和体内研究。
Molecules. 2022 Oct 17;27(20):6964. doi: 10.3390/molecules27206964.
3
Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma.

本文引用的文献

1
Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells.藏红花酸通过增加人胃腺癌 AGS 细胞中的 Bax/Bcl-2 比值和半胱氨酸天冬氨酸蛋白酶的激活来诱导细胞凋亡。
DNA Cell Biol. 2013 Feb;32(2):50-7. doi: 10.1089/dna.2012.1866.
2
Isolation and identification of the phenolic compounds from the roots of Sanguisorba officinalis L. and their antioxidant activities.从苦菜根部分离鉴定酚类化合物及其抗氧化活性。
Molecules. 2012 Nov 23;17(12):13917-22. doi: 10.3390/molecules171213917.
3
Methanol extract of Sanguisorba officinalis L. with cytotoxic activity against PC3 human prostate cancer cells.
植物化学物质作为一种替代或综合选择，与肝细胞癌的传统治疗方法联合使用。
Cancers (Basel). 2021 Nov 17;13(22):5753. doi: 10.3390/cancers13225753.
4
A Comprehensive Review of Genus : Traditional Uses, Chemical Constituents and Medical Applications.某属的综合综述：传统用途、化学成分与医学应用
Front Pharmacol. 2021 Sep 20;12:750165. doi: 10.3389/fphar.2021.750165. eCollection 2021.
5
Determination of Triterpenoids and Phenolic Acids from L. by HPLC-ELSD and Its Application.采用 HPLC-ELSD 法测定了 L. 中的三萜和酚酸，并将其应用于 L. 中三萜和酚酸的含量测定。
Molecules. 2021 Jul 27;26(15):4505. doi: 10.3390/molecules26154505.
6
Repurposing Ziyuglycoside II Against Colorectal Cancer Orchestrating Apoptosis and Autophagy.紫萸糖苷II用于治疗结直肠癌并调控细胞凋亡和自噬的新用途
Front Pharmacol. 2020 Sep 18;11:576547. doi: 10.3389/fphar.2020.576547. eCollection 2020.
7
Chemical Composition, Antioxidant and Antimicrobial Activities of L. Extracts.L.提取物的化学成分、抗氧化及抗菌活性
Pharm Chem J. 2016;50(4):244-249. doi: 10.1007/s11094-016-1431-0. Epub 2016 Aug 11.
8
Synthesis, Anticancer Activity, and Apoptosis Induction of Novel 3,6-Diazaphenothiazines.新型 3,6-二氮杂吩噻嗪的合成、抗癌活性及诱导细胞凋亡作用。
Molecules. 2019 Jan 12;24(2):267. doi: 10.3390/molecules24020267.
9
Simultaneous Determination and Pharmacokinetics Study of Six Triterpenes in Rat Plasma by UHPLC-MS/MS after Oral Administration of L. Extract.灌胃服用 L. 提取物后 UHPLC-MS/MS 法同时测定大鼠血浆中 6 种三萜类成分及其药代动力学研究
Molecules. 2018 Nov 15;23(11):2980. doi: 10.3390/molecules23112980.
10
A Sample and Sensitive HPLC-MS/MS Method for Simultaneous Determination of Ziyuglycoside I and Its Metabolite Ziyuglycoside II in Rat Pharmacokinetics.一种用于同时测定大鼠药代动力学中梓醇苷 I 及其代谢物梓醇苷 II 的灵敏高效液相色谱-串联质谱法。
Molecules. 2018 Feb 28;23(3):543. doi: 10.3390/molecules23030543.
地榆甲醇提取物对人前列腺癌 PC3 细胞的细胞毒性作用。
Mol Med Rep. 2012 Sep;6(3):670-4. doi: 10.3892/mmr.2012.949. Epub 2012 Jun 14.
4
Anti-tumor and immunomodulating activities of a polysaccharide from the root of Sanguisorba officinalis L.地榆根多糖的抗肿瘤和免疫调节活性
Int J Biol Macromol. 2012 Nov;51(4):484-8. doi: 10.1016/j.ijbiomac.2012.05.029. Epub 2012 May 30.
5
Targeted therapy for gastric cancer.胃癌的靶向治疗。
Curr Treat Options Oncol. 2012 Sep;13(3):377-89. doi: 10.1007/s11864-012-0192-6.
6
The intrinsic apoptosis pathways as a target in anticancer therapy.内在凋亡途径作为抗癌治疗的靶点。
Curr Pharm Biotechnol. 2012 Jun;13(8):1426-38. doi: 10.2174/138920112800784989.
7
Effect of Sanguisorba officinalis L on breast cancer growth and angiogenesis.地榆对乳腺癌生长和血管生成的影响。
Expert Opin Ther Targets. 2012 Mar;16 Suppl 1:S79-89. doi: 10.1517/14728222.2011.642371. Epub 2012 Feb 9.
8
Caspase-3 activation as a bifurcation point between plasticity and cell death.Caspase-3 的激活作为可塑性和细胞死亡之间的分岔点。
Neurosci Bull. 2012 Feb;28(1):14-24. doi: 10.1007/s12264-012-1057-5.
9
Natural products: an evolving role in future drug discovery.天然产物：在未来药物发现中的不断演变的作用。
Eur J Med Chem. 2011 Oct;46(10):4769-807. doi: 10.1016/j.ejmech.2011.07.057. Epub 2011 Aug 16.
10
Treatment of gastric cancer with peritoneal carcinomatosis by cytoreductive surgery and HIPEC: a systematic review of survival, mortality, and morbidity.腹腔热灌注化疗联合细胞减灭术治疗腹膜转移癌：一项生存、死亡率和发病率的系统评价。
J Surg Oncol. 2011 Nov 1;104(6):692-8. doi: 10.1002/jso.22017. Epub 2011 Jun 28.