Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
J Glaucoma. 2015 Mar;24(3):e7-13. doi: 10.1097/IJG.0b013e31829521f2.
We report 2 bilateral cases that presented as primary ocular hypertension and primary angle-closure glaucoma, respectively; however, they were subsequently discovered to be harboring secretory pituitary tumors. After transsphenoidal tumor resection, intraocular pressures (IOPs) in all 4 eyes returned to normal levels. Sudden rise in IOP then again served as a primary manifestation of relapse in the second patient with growth hormone secreting pituitary tumor. It was not found feasible for resurgery; thus, patient needed trabeculectomy in both eyes to achieve an optimum control of intraocular tension. We conclude that pituitary adenomas may mimic primary glaucoma without producing vertical hemianopia and cause a reversible rise in IOP. Furthermore, a careful ongoing expert ophthalmologic assessment may serve as a useful clinical marker for early relapse in these tumors.
我们报告 2 例双侧病例，分别表现为原发性眼高压和原发性闭角型青光眼；然而，随后发现它们分别患有分泌性垂体肿瘤。经蝶窦肿瘤切除后，4 只眼中的眼内压（IOP）均恢复正常水平。在第二位生长激素分泌性垂体肿瘤患者中，IOP 的突然升高再次成为复发的主要表现。由于肿瘤再次复发，再次手术已不可行；因此，患者双眼均需要行小梁切除术以实现眼压的最佳控制。我们的结论是，垂体腺瘤可能在不产生垂直偏盲的情况下模拟原发性青光眼，并导致 IOP 可逆性升高。此外，持续进行的专家眼科评估可能成为这些肿瘤早期复发的有用临床标志物。
