Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Phytother Res. 2014 May;28(5):784-7. doi: 10.1002/ptr.5053. Epub 2013 Aug 22.
One new flavonoid glycoside, along with three known flavonoid glycosides were isolated from the stem bark of Margaritaria discoidea, which is traditionally used in the management of wounds and skin infections in Ghana. The new flavonoid glycoside was elucidated as hydroxygenkwanin-8-C-[α-rhamnopyranosyl-(1 → 6)]-β-glucopyranoside (1) on the basis of spectroscopic analysis. The isolated compounds demonstrated free-radical scavenging as well as some level of antibacterial activities. Microorganisms including Staphylococcus aureus are implicated in inhibiting or delaying wound healing. Therefore, any agent capable of reducing or eliminating the microbial load present in a wound as well as decreasing the levels of reactive oxygen species may facilitate the healing process. These findings therefore provide some support to the ethnopharmacological usage of the plant in the management of wounds.
从传统上用于治疗加纳伤口和皮肤感染的 Margaritaria discoidea 的茎皮中分离得到一种新的类黄酮糖苷和三种已知的类黄酮糖苷。新的类黄酮糖苷通过光谱分析被阐明为 hydroxygenkwanin-8-C-[α-rhamnopyranosyl-(1 → 6)]-β-glucopyranoside (1)。根据光谱分析，分离得到的化合物具有自由基清除活性和一定的抗菌活性。包括金黄色葡萄球菌在内的微生物被认为会抑制或延迟伤口愈合。因此，任何能够减少或消除伤口中微生物负荷以及降低活性氧水平的药物都可能促进愈合过程。这些发现为该植物在治疗伤口方面的传统应用提供了一些支持。
