Ojaimi Samar, Lin Ming-Wei, Singh Kasha P, Woolley Ian
Department of Infectious Diseases, Southern Health, Clayton, Australia.
Int J STD AIDS. 2014 Feb;25(2):77-88. doi: 10.1177/0956462413495671. Epub 2013 Jul 25.
Vasculitis has long been associated with chronic viral infections, thus the twin perils of the infection and the immune response against it that bedevils the specialties of infection and immunity. After HIV was identified, it too became associated with vasculitic syndromes. Later, hepatitis C virus was also isolated, identified and described with its own spectrum of vasculitic diseases, including hepatitis C virus-associated cryoglobulinaemia. With the increasing prevalence of HIV and hepatitis C virus coinfection, there has come an increasing recognition of the range of vasculitides that can occur in this population leading to significant morbidity, diagnostic and treatment challenges. In this review, we examine the epidemiology, pathogenesis and general principles of treatment of these systemic diseases in HIV/hepatitis C virus coinfected individuals.
血管炎长期以来一直与慢性病毒感染相关，因此感染及其引发的免疫反应这两大危险因素困扰着感染科和免疫科。在人类免疫缺陷病毒（HIV）被发现后，它也与血管炎综合征相关。后来，丙型肝炎病毒也被分离、鉴定并描述了其自身一系列血管炎疾病，包括丙型肝炎病毒相关冷球蛋白血症。随着HIV和丙型肝炎病毒合并感染的患病率不断上升，人们越来越认识到这一人群中可能出现的各种血管炎，这导致了严重的发病率、诊断和治疗挑战。在这篇综述中，我们研究了HIV/丙型肝炎病毒合并感染个体中这些全身性疾病的流行病学、发病机制和一般治疗原则。
