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血栓反应蛋白和血管内皮生长因子受体：在炎症性肠病中是否存在相关性？

Thrombospondin and VEGF-R: is there a correlation in inflammatory bowel disease?

机构信息

Department of Pathology, Professor Witold Orlowski Public Clinical Hospital, Medical Center for Postgraduate Education, Czerniakowska 231, 00-416 Warsaw, Poland.

出版信息

Mediators Inflamm. 2013;2013:908259. doi: 10.1155/2013/908259. Epub 2013 Jul 18.

DOI:10.1155/2013/908259
PMID:23970816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3732645/
Abstract

Up to date several authors discussed interactions between cells forming inflammatory infiltrates in the course of inflammatory bowel disease (IBD), mainly dealing with endoscopic biopsy specimens. These usually contain only mucosa. We have evaluated full bowel wall sections, which seems to be especially important in patients with Crohn's disease (CD). The purpose of our study was to evaluate the relationship between vascular density and expression of thrombospondin-1 (TSP-1) and vascular endothelial growth factor receptor 1 (VEGFR-1) in full-thickness tissue fragments of intestinal wall taken from patients after colectomy, comparing those with IBD to non-IBD control group. Histological sections were immunostained with antibodies against CD-31, TSP-1, and VEGFR-1 and analyzed by pathologists with the use of computer-assisted morphometrics. Our research showed significantly higher vascular density and vascular area percentage in all layers of bowel wall in patients with CD when compared to control. We have also demonstrated differences in vascular density distribution between ulcerative colitis (CU) and CD and between CU and control. However we have not found statistically significant correlation between those findings and VEGFR-1 or TSP-1 expression. Our results might suggest existence of different, TSP-1 independent pathways of antiangiogenesis in IBD.

摘要

目前已有多位作者讨论了在炎症性肠病（IBD）过程中形成炎症浸润的细胞之间的相互作用，主要涉及内镜活检标本。这些标本通常仅包含黏膜。我们评估了全肠壁切片，这在克罗恩病（CD）患者中似乎尤为重要。我们研究的目的是评估从结肠切除术后患者的肠壁全层组织切片中血管密度与血小板反应蛋白-1（TSP-1）和血管内皮生长因子受体 1（VEGFR-1）表达之间的关系，将这些患者与 IBD 对照组进行比较。用针对 CD-31、TSP-1 和 VEGFR-1 的抗体对组织切片进行免疫染色，并由病理学家使用计算机辅助形态计量学进行分析。我们的研究表明，与对照组相比，CD 患者的肠壁各层的血管密度和血管面积百分比均显著升高。我们还发现了溃疡性结肠炎（UC）和 CD 之间以及 UC 和对照组之间血管密度分布的差异。然而，我们没有发现这些发现与 VEGFR-1 或 TSP-1 表达之间存在统计学上的显著相关性。我们的结果可能表明 IBD 中存在不同的、TSP-1 独立的抗血管生成途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053a/3732645/a54d03597846/MI2013-908259.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053a/3732645/7203b42aac29/MI2013-908259.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053a/3732645/a54d03597846/MI2013-908259.009.jpg

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