Department of Trauma and Orthopedic Surgery, Trauma Center Murnau, Murnau, Germany.
Arthroscopy. 2013 Oct;29(10):1702-11. doi: 10.1016/j.arthro.2013.06.014. Epub 2013 Aug 21.
Biologics may help to optimize the healing environment after rotator cuff repair. Mesenchymal stem cells (MSCs) may have the potential to regenerate a physiological enthesis, thereby improving healing at the repair site after rotator cuff repair.
The PubMed database was searched in May 2013. Only in vivo and in vitro studies reporting on stem cell use in the rotator cuff of humans or animals were included. Exclusion criteria consisted of the following: Level V evidence, systematic reviews, and studies reporting preliminary results.
This query resulted in 141 citations. Of these, 90 were excluded based on the title of the study. A final group of 17 studies was included in this review (9 in vivo animal studies, 5 in vitro human studies, 1 in vitro animal study, 1 study reporting in vitro human and in vivo animal results, and 1 study reporting on clinical outcomes of human patients).
The current literature regarding therapeutic use of MSCs in shoulder surgery is limited. Although in vivo animal studies have shown some promising approaches to enhance tendon-to-bone healing, the use of MSCs for shoulder surgery should still be regarded as an experimental technique. Further basic and clinical research is needed until a procedure can be defined for the routine use of these cells in shoulder surgery.
生物制剂可能有助于优化肩袖修复后的愈合环境。间充质干细胞（MSCs）有可能再生生理性附着点，从而改善肩袖修复后修复部位的愈合。
2013 年 5 月在 PubMed 数据库中进行检索。仅纳入了关于干细胞在人类或动物肩袖中应用的体内和体外研究。排除标准包括：证据等级 V、系统评价和报告初步结果的研究。
本次检索得到了 141 条引用。其中，90 条根据研究标题被排除。最终纳入了 17 项研究（9 项体内动物研究、5 项体外人类研究、1 项体外动物研究、1 项同时报告体外人类和体内动物结果的研究以及 1 项报告人类患者临床结果的研究）。
目前关于间充质干细胞在肩部手术中的治疗应用的文献有限。尽管体内动物研究已经提出了一些有前景的方法来增强肌腱-骨愈合，但间充质干细胞在肩部手术中的应用仍应被视为一种实验技术。在确定这些细胞在肩部手术中的常规应用程序之前，还需要进一步的基础和临床研究。
