Clinical and Experimental Endocrinology, Katholieke Universiteit (KU) Leuven, Campus Gasthuisberg, O&N 1 Herestraat 49, Box 902, 3000 Leuven, Belgium.
Trends Endocrinol Metab. 2013 Nov;24(11):561-8. doi: 10.1016/j.tem.2013.07.002. Epub 2013 Aug 21.
The beneficial effects of vitamin D supplementation for several health-related issues, including the prevention of diabetes, are a topic of intense discussion. Data from epidemiological studies suggest a correlation between vitamin D deficiency and higher prevalence of both type 1 and type 2 diabetes (T1D and T2D). In animal models, vitamin D deficiency predisposes to diabetes whereas vitamin D supplementation prevents disease. Nevertheless, well-designed clinical intervention studies are lacking. We discuss here the evidence for a role of vitamin D in diabetes and propose that vitamin D deficiency should be avoided, especially in all at-risk people. This should be possible by implementing global guidelines and by focusing on daily dietary supplementation with small doses of vitamin D.
维生素 D 补充对多种健康相关问题（包括糖尿病预防）的有益影响是一个激烈讨论的话题。来自流行病学研究的数据表明，维生素 D 缺乏与 1 型和 2 型糖尿病（T1D 和 T2D）的更高患病率之间存在相关性。在动物模型中，维生素 D 缺乏易患糖尿病，而维生素 D 补充可预防疾病。然而，缺乏精心设计的临床干预研究。我们在这里讨论了维生素 D 在糖尿病中的作用的证据，并提出应避免维生素 D 缺乏，尤其是在所有高危人群中。这可以通过实施全球指南和专注于每日膳食补充小剂量维生素 D 来实现。
