Zhang Binjie, Zhao Wenli, Tu Jinli, Wang Xueying, Hao Yu, Wang Hongwu, Zhao Ye, Mizuno Kaito, Tseng Yiider, Bu Huaien
Graduate School, Tianjin University of Traditional Chinese Medicine.
Department of Neurology, Nankai Hospital, Tianjin Academy of Integrative Medicine, Tianjin, China.
Medicine (Baltimore). 2019 Nov;98(48):e18118. doi: 10.1097/MD.0000000000018118.
Vitamin D is a fat-soluble vitamin that is related to the health of the human body and is an indispensable nutrient for human beings. Some studies indicated that type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) may be associated with vitamin D deficiency, but the current understanding of this point of view remains controversial. This study aimed to evaluate the correlation between serum 25-hydroxyl vitamin D (25 [OH] D) concentration and DPN in patients with T2DM by a meta-analysis, and to provide a reference for doctors.
Relevant studies were selected from the PubMed, Cochrane Library, China National Knowledge Infrastructure, VIP databases, and Wanfang Data Knowledge Service Platform databases dating from 2000 to December 2017. A total of 75 articles related to serum 25 (OH) D and DPN were selected from 2000 to December 2017. Based on the inclusion and exclusion criteria of the literature, a quality assessment was conducted using the Newcastle-Ottawa scale, and a meta-analysis was performed by RevMan5.3 statistical software.
Thirteen studies that involved a total of 2814 type 2 diabetic patients were finally included into the meta-analysis. Meta-analysis results, heterogeneity test showed that, P < .000 01, I = 92%, calculation by random effect model revealed that, the serum concentration of 25 (OH) D in T2DM combined with DPN group was lower than that in the group without DPN (weighted mean difference = -0.74, 95% confidence interval: -1.03 to -0.46) CONCLUSIONS:: Vitamin D is associated with type 2 DPN (DPN), and vitamin D deficiency can lead to an increased risk of type 2 DPN. However, more high-quality research is needed.
维生素D是一种与人体健康相关的脂溶性维生素，是人类不可或缺的营养素。一些研究表明，2型糖尿病（T2DM）合并糖尿病周围神经病变（DPN）可能与维生素D缺乏有关，但目前对这一观点的认识仍存在争议。本研究旨在通过荟萃分析评估T2DM患者血清25-羟基维生素D（25[OH]D）浓度与DPN之间的相关性，为医生提供参考。
从2000年至2017年12月的PubMed、Cochrane图书馆、中国知网、维普数据库和万方数据知识服务平台数据库中选取相关研究。2000年至2017年12月共筛选出75篇与血清25（OH）D和DPN相关的文章。根据文献的纳入和排除标准，采用纽卡斯尔-渥太华量表进行质量评估，并使用RevMan5.3统计软件进行荟萃分析。
最终纳入荟萃分析的有13项研究，共涉及2814例2型糖尿病患者。荟萃分析结果、异质性检验显示，P<0.00001，I=92%，采用随机效应模型计算得出，T2DM合并DPN组的血清25（OH）D浓度低于无DPN组（加权平均差=-0.74，95%置信区间：-1.03至-0.46）。结论：维生素D与2型DPN相关，维生素D缺乏可导致2型DPN风险增加。然而，还需要更多高质量的研究。
