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PACP 和 PAC1 受体基因的遗传多态性与广泛性焦虑障碍患者文拉法辛 XR 的治疗反应

Genetic polymorphisms in the PACAP and PAC1 receptor genes and treatment response to venlafaxine XR in generalized anxiety disorder.

机构信息

Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, United States.

出版信息

Psychiatry Res. 2013 Dec 30;210(3):1299-300. doi: 10.1016/j.psychres.2013.07.038. Epub 2013 Aug 22.

DOI:10.1016/j.psychres.2013.07.038
PMID:23972788
Abstract

The pituitary adenylate cyclase-activating peptide (PACAP) and its receptor (PAC1) are involved in stress response and anxiety. Genotypes for PACAP/PAC1 were examined for effects on treatment response to venlafaxine XR in generalized anxiety disorder. The Asp54Gly (rs2856966) variant in the PACAP gene was associated with better treatment outcome.

摘要

垂体腺苷酸环化酶激活肽 (PACAP)及其受体 (PAC1) 参与应激反应和焦虑。检查了 PACAP/PAC1 的基因型对广泛性焦虑障碍文拉法辛 XR 治疗反应的影响。PACAP 基因中的 Asp54Gly(rs2856966) 变体与更好的治疗结果相关。

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