Goossens E, Tournaye H
Biology of the Testis (BITE), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussel, Belgique.
Gynecol Obstet Fertil. 2013 Sep;41(9):529-31. doi: 10.1016/j.gyobfe.2013.07.013. Epub 2013 Aug 21.
Spermatogonial stem cells (SSC) are the founder cells of spermatogenesis and are responsible for the lifelong production of spermatozoa. The cryopreservation and transplantation of these cells has been proposed as a fertility preservation strategy for young boys at risk for stem cell loss, i.e. patients undergoing chemotherapy for cancer or as a conditioning treatment for bone marrow transplantation. To prevent lifelong sterility in boys, two fertility restoration strategies are being developed: the injection of SSC and the grafting of testicular tissue containing SSC. Depending on the disease of the patient one of these two approaches will be applicable. Grafting has the advantage that SSC can reside within their natural niche, preserving the interactions between germ cells and their supporting cells and may therefore be regarded as the first choice strategy. However, in cases where the risk for malignant contamination of the testicular tissue is real, e.g. leukemia, transplantation of SSC by injection is preferable over grafting.
精原干细胞（SSC）是精子发生的起始细胞，负责精子的终身生成。这些细胞的冷冻保存和移植已被提议作为一种生育力保存策略，用于面临干细胞丢失风险的年轻男孩，即接受癌症化疗的患者或作为骨髓移植预处理的患者。为防止男孩终身不育，正在开发两种生育力恢复策略：注射精原干细胞和移植含有精原干细胞的睾丸组织。根据患者的疾病情况，这两种方法中的一种将适用。移植的优点是精原干细胞可以驻留在其天然微环境中，保留生殖细胞与其支持细胞之间的相互作用，因此可被视为首选策略。然而，在睾丸组织存在恶性污染风险的情况下，例如白血病，通过注射移植精原干细胞比移植睾丸组织更可取。
