Feldberg Dov, Purandare Nikhil
Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tivka, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Int J Gynaecol Obstet. 2025 Jun;169(3):891-894. doi: 10.1002/ijgo.16174. Epub 2025 Jan 21.
All patients where the cancer treatment has gonadotoxic potential should be referred for oncofertility advice. The effect of chemotherapy and radiotherapy on the human ovary can vary from no impact to full-blown premature ovarian failure due to hormonal and follicular depletion. Total contraindications to fertility cryopreservation include acute malignancy that requires immediate lifesaving therapy. In prepubertal girls, the only option for urgent fertility preservation is ovarian tissue cryopreservation. Prepubertal testicular tissue cryopreservation is experimental.
所有接受具有性腺毒性潜力的癌症治疗的患者都应转诊以获取生育力保护方面的建议。化疗和放疗对人类卵巢的影响各不相同，从无影响到因激素和卵泡耗竭导致的完全性早发性卵巢功能不全。生育力冷冻保存的绝对禁忌证包括需要立即进行挽救生命治疗的急性恶性肿瘤。对于青春期前女孩，紧急生育力保存的唯一选择是卵巢组织冷冻保存。青春期前睾丸组织冷冻保存尚处于实验阶段。
