骨关节炎疼痛的流行病学和影响。
The epidemiology and impact of pain in osteoarthritis.
机构信息
Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA.
出版信息
Osteoarthritis Cartilage. 2013 Sep;21(9):1145-53. doi: 10.1016/j.joca.2013.03.018.
Abstract
Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide, largely due to pain, the primary symptom of the disease. The pain experience in knee OA in particular is well-recognized as typically transitioning from intermittent weight-bearing pain to a more persistent, chronic pain. Methods to validly assess pain in OA studies have been developed to address the complex nature of the pain experience. The etiology of pain in OA is recognized to be multifactorial, with both intra-articular and extra-articular risk factors. Nonetheless, greater insights are needed into pain mechanisms in OA to enable rational mechanism-based management of pain. Consequences of pain related to OA contribute to a substantial socioeconomic burden.
摘要
骨关节炎（OA）是最常见的关节炎类型，也是全球范围内导致残疾的主要原因，主要是由于疼痛，这是该疾病的主要症状。特别是膝关节 OA 的疼痛体验被认为通常从间歇性承重疼痛转变为更持久的慢性疼痛。为了解决疼痛体验的复杂性，已经开发出了有效的评估 OA 研究中疼痛的方法。OA 中疼痛的病因被认为是多因素的，包括关节内和关节外的危险因素。尽管如此，仍需要更多地了解 OA 中的疼痛机制，以便对疼痛进行合理的基于机制的管理。与 OA 相关的疼痛后果导致了巨大的社会经济负担。
相似文献
1
The epidemiology and impact of pain in osteoarthritis.骨关节炎疼痛的流行病学和影响。
Osteoarthritis Cartilage. 2013 Sep;21(9):1145-53. doi: 10.1016/j.joca.2013.03.018.
2
Pain in osteoarthritis. Implications for optimal management.骨关节炎疼痛。对最佳管理的影响。
Joint Bone Spine. 2018 Jul;85(4):429-434. doi: 10.1016/j.jbspin.2017.08.002. Epub 2017 Sep 6.
3
The Association of Perceived Memory Loss with Osteoarthritis and Related Joint Pain in a Large Appalachian Population.在一个大型阿巴拉契亚人群中，感知记忆丧失与骨关节炎和相关关节疼痛的关联。
Pain Med. 2018 Jul 1;19(7):1340-1356. doi: 10.1093/pm/pnx107.
4
Impact of first metatarsophalangeal joint osteoarthritis on health-related quality of life.第一跖趾关节骨关节炎对健康相关生活质量的影响。
Arthritis Care Res (Hoboken). 2012 Nov;64(11):1691-8. doi: 10.1002/acr.21729.
5
Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain.英国国家卫生与临床优化研究所骨关节炎指南在初级保健中的应用：一项针对有关节疼痛的老年人的调查。
BMC Musculoskelet Disord. 2018 Aug 17;19(1):295. doi: 10.1186/s12891-018-2196-2.
6
Genomics of pain in osteoarthritis.骨关节炎疼痛的基因组学。
Osteoarthritis Cartilage. 2013 Sep;21(9):1374-82. doi: 10.1016/j.joca.2013.06.010.
7
Body mass and osteoarthritic pain: results from a study in general practice.体重与骨关节炎疼痛：来自普通实践研究的结果。
Clin Exp Rheumatol. 2013 Nov-Dec;31(6):843-9. Epub 2013 Oct 17.
8
Electro-acupuncture for treatment of knee pain from osteoarthritis and the possible endocrinology changes: a study protocol for a randomized controlled trial.电针治疗骨关节炎膝关节疼痛及可能的内分泌变化：一项随机对照试验的研究方案
Trials. 2015 Jun 3;16:248. doi: 10.1186/s13063-015-0766-2.
9
Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis: radiofrequency neurotomy of the genicular nerves or intra-articular injection?对于膝关节骨关节炎慢性疼痛的临床治疗，哪一种更有效：膝神经射频切断术还是关节内注射？
Int J Rheum Dis. 2018 Oct;21(10):1772-1778. doi: 10.1111/1756-185X.12925. Epub 2016 Aug 12.
10
New horizons in osteoarthritis.骨关节炎的新视野。
Age Ageing. 2013 May;42(3):272-8. doi: 10.1093/ageing/aft043. Epub 2013 Apr 8.
引用本文的文献
1
Histopathological evaluation of synovial tissue in advanced osteoarthritis: A retrospective study based on total knee arthroplasty specimens.晚期骨关节炎滑膜组织的组织病理学评估：一项基于全膝关节置换术标本的回顾性研究。
Medicine (Baltimore). 2025 Aug 29;104(35):e44152. doi: 10.1097/MD.0000000000044152.
2
Mediating role of effusion-synovitis in knee pain worsening following quadriceps weakness: data from the osteoarthritis initiative.积液性滑膜炎在股四头肌无力后膝关节疼痛加重中的中介作用：来自骨关节炎倡议的数据。
BMC Musculoskelet Disord. 2025 Sep 2;26(1):847. doi: 10.1186/s12891-025-09113-w.
3
Pharmacist-Driven Chondroprotection in Osteoarthritis: A Multifaceted Approach Using Patient Education, Information Visualization, and Lifestyle Integration.药剂师主导的骨关节炎软骨保护：一种采用患者教育、信息可视化和生活方式整合的多方面方法。
Pharmacy (Basel). 2025 Aug 1;13(4):106. doi: 10.3390/pharmacy13040106.
4
Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.骨关节炎疼痛中的外周神经元致敏和神经血管重塑。
Nat Rev Rheumatol. 2025 Aug 12. doi: 10.1038/s41584-025-01280-3.
5
Longitudinal Trajectories of Pain Sensitization over Nine Years in People with or at Risk of Knee Osteoarthritis.膝关节骨关节炎患者或有膝关节骨关节炎风险人群九年间疼痛敏化的纵向轨迹
Arthritis Care Res (Hoboken). 2025 Aug 12. doi: 10.1002/acr.25626.
6
Development of Explainable Machine Learning Models to Predict Outcomes After Platelet-Rich Plasma Injections for Knee Osteoarthritis.用于预测膝关节骨关节炎富血小板血浆注射后结果的可解释机器学习模型的开发。
Orthop J Sports Med. 2025 Aug 7;13(8):23259671251349743. doi: 10.1177/23259671251349743. eCollection 2025 Aug.
7
Controlling Joint Instability Reduces Inflammatory Pain in Early Knee Osteoarthritis.控制关节不稳可减轻早期膝关节骨关节炎的炎性疼痛。
Cureus. 2025 Jul 11;17(7):e87711. doi: 10.7759/cureus.87711. eCollection 2025 Jul.
8
The Efficacy and Safety of Use of Cannabis and Cannabinoid Products for Pain Relief in Orthopaedic Conditions and Trauma.大麻及大麻素类产品用于缓解骨科疾病和创伤疼痛的疗效与安全性。
Cureus. 2025 Jul 3;17(7):e87208. doi: 10.7759/cureus.87208. eCollection 2025 Jul.
9
Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.骨科疾病中的核酸适配体：治疗骨病的潜在治疗剂。
Bone Res. 2025 Jul 24;13(1):71. doi: 10.1038/s41413-025-00447-8.
10
Cartilage lesions are not the main factor influencing pain and functional impairment in early knee osteoarthritis : a multivariate analysis on intra- and extra-articular factors affecting symptoms in over 200 knees.软骨损伤并非早期膝关节骨关节炎疼痛和功能障碍的主要影响因素：对200多个膝关节的关节内和关节外影响症状因素的多变量分析
Bone Jt Open. 2025 Jul 16;6(7):828-835. doi: 10.1302/2633-1462.67.BJO-2025-0010.R1.
本文引用的文献
1
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.291 种疾病和伤害导致的伤残调整生命年（DALYs）在 21 个地区，1990-2010 年：全球疾病负担研究 2010 的系统分析。
Lancet. 2012 Dec 15;380(9859):2197-223. doi: 10.1016/S0140-6736(12)61689-4.
2
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.2010 年全球疾病负担研究：1990-2010 年 289 种疾病和伤害的 1160 种后遗症导致的残疾生存年数的系统分析。
Lancet. 2012 Dec 15;380(9859):2163-96. doi: 10.1016/S0140-6736(12)61729-2.
3
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial.雷奈酸锶治疗膝骨关节炎的疗效和安全性：一项双盲、随机、安慰剂对照试验的结果。
Ann Rheum Dis. 2013 Feb;72(2):179-86. doi: 10.1136/annrheumdis-2012-202231. Epub 2012 Nov 1.
4
Is symptomatic knee osteoarthritis a risk factor for a trajectory of fast decline in gait speed? Results from a longitudinal cohort study.症状性膝骨关节炎是否是步态速度快速下降轨迹的危险因素？一项纵向队列研究的结果。
Arthritis Care Res (Hoboken). 2013 Feb;65(2):187-94. doi: 10.1002/acr.21816.
5
Metabolic factors in osteoarthritis: obese people do not walk on their hands.骨关节炎中的代谢因素：肥胖者不会用手行走。
Arthritis Res Ther. 2012 Jul 19;14(4):123. doi: 10.1186/ar3894.
6
Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis.疼痛性骨关节炎的定量感觉测试：系统评价和荟萃分析。
Osteoarthritis Cartilage. 2012 Oct;20(10):1075-85. doi: 10.1016/j.joca.2012.06.009. Epub 2012 Jul 13.
7
Risk of sick leave and disability pension in working-age women and men with knee osteoarthritis.膝骨关节炎患者中青年女性和男性请病假和残疾津贴的风险。
Ann Rheum Dis. 2013 Mar;72(3):401-5. doi: 10.1136/annrheumdis-2012-201472. Epub 2012 Jun 7.
8
Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP).成人疼痛测量方法：疼痛视觉模拟量表（VAS疼痛）、疼痛数字评定量表（NRS疼痛）、麦吉尔疼痛问卷（MPQ）、简化麦吉尔疼痛问卷（SF-MPQ）、慢性疼痛分级量表（CPGS）、简短健康调查36项身体疼痛量表（SF-36 BPS）以及间歇性和持续性骨关节炎疼痛测量量表（ICOAP）。
Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S240-52. doi: 10.1002/acr.20543.
9
Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: a cohort study.体重变化与膝关节骨关节炎症状患者的疼痛和功能变化的关系：一项队列研究。
Arthritis Care Res (Hoboken). 2013 Jan;65(1):15-22. doi: 10.1002/acr.21692.
10
Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study.疼痛应对技能训练和生活方式行为体重管理对膝骨关节炎患者的影响：一项随机对照研究。
Pain. 2012 Jun;153(6):1199-1209. doi: 10.1016/j.pain.2012.02.023. Epub 2012 Apr 12.
Zotero 插件