Kramer Michael R, Williamson Rebecca
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, United States.
Spat Spatiotemporal Epidemiol. 2013 Sep;6:25-35. doi: 10.1016/j.sste.2013.05.002. Epub 2013 May 31.
There is epidemiologic evidence that women who experience preterm birth (PTB) are at elevated risk for cardiovascular disease (CVD) later in life. Each outcome independently has noted spatial and socioeconomic gradients; we test for spatial structure in the population correlation of the two.
Exploratory spatial data analysis and multivariate Bayesian spatial models were fit to describe the spatial correlation of PTB with CVD among women in Georgia counties from 2002 to 2006.
Global Moran's I and local-indicators of spatial association statistics suggest significant co-occurrence of CVD and PTB. Bayesian posterior estimates for multivariate correlation of these outcomes range from r=0.11-0.34 for CVD and PTB. Significant spatial correlation persists with control for county covariates among whites but not blacks.
Modest evidence for spatial structure of the ecologic correlation of PTB and women's CVD is consistent with a lifecourse perspective on socially clustered determinants of health.
有流行病学证据表明，经历过早产（PTB）的女性在晚年患心血管疾病（CVD）的风险会升高。每种结果各自都呈现出空间和社会经济梯度；我们检验两者在人群中的相关性是否存在空间结构。
运用探索性空间数据分析和多变量贝叶斯空间模型，以描述2002年至2006年佐治亚州各县女性中早产与心血管疾病之间的空间相关性。
全局莫兰指数（Global Moran's I）和局部空间关联指标统计表明，心血管疾病和早产显著共存。这些结果多变量相关性的贝叶斯后验估计值，心血管疾病和早产的范围为r = 0.11 - 0.34。在对白人的县协变量进行控制后，显著的空间相关性依然存在，但黑人中不存在。
早产与女性心血管疾病的生态相关性存在空间结构的适度证据，这与从生命历程角度看待健康的社会聚集性决定因素是一致的。
