De Ceuninck Frédéric, Fradin Armel, Pastoureau Philippe
Institut de Recherches Servier, Department of Rheumatology, 11 rue des Moulineaux, Suresnes 92150, France.
Institut de Recherches Servier, Department of Rheumatology, 11 rue des Moulineaux, Suresnes 92150, France.
Drug Discov Today. 2014 Mar;19(3):305-11. doi: 10.1016/j.drudis.2013.08.004. Epub 2013 Aug 20.
Osteoarthritis, a disease characterized by cartilage degradation, abnormal subchondral bone remodelling and some grade of inflammation, and sarcopenia, a condition of pathological muscle weakness associated with altered muscle mass, strength, and function, are prevalent disorders in elderly people. There is increasing evidence that decline in lower limb muscle strength is associated with knee or hip osteoarthritis in a context of pain, altered joint stability, maladapted postures and defective neuromuscular communication. At the cellular and molecular levels, chondrocytes and myoblasts share common pathological targets and pathways, and the close anatomical location of both cell types suggest a possibility of paracrine communication. In this review, we examine the relationship between osteoarthritis and sarcopenia in the musculoskeletal field, and discuss the potential advantage of concomitant therapies, or how each disorder may benefit from treatment of the other.
骨关节炎是一种以软骨退化、软骨下骨异常重塑以及一定程度炎症为特征的疾病，而肌肉减少症是一种与肌肉质量、力量和功能改变相关的病理性肌肉无力状态，这两种疾病在老年人中都很常见。越来越多的证据表明，在疼痛、关节稳定性改变、姿势不当和神经肌肉沟通缺陷的情况下，下肢肌肉力量下降与膝关节或髋关节骨关节炎有关。在细胞和分子水平上，软骨细胞和成肌细胞有共同的病理靶点和途径，而且这两种细胞类型在解剖位置上相近，提示存在旁分泌通讯的可能性。在这篇综述中，我们研究了肌肉骨骼领域中骨关节炎与肌肉减少症之间的关系，并讨论了联合治疗的潜在优势，或者每种疾病如何可能从另一种疾病的治疗中获益。
