Dolan R J, Poynton A M, Bridges P K, Trimble M R
Royal Free Hospital School of Medicine, London.
Br J Psychiatry. 1990 Jul;157:107-10. doi: 10.1192/bjp.157.1.107.
The MRI T1 proton relaxation values were assessed in 14 patients with bipolar affective disorder and 10 with a unipolar disorder and a matched normal control group. The T1 values in the frontal white matter of patients significantly exceeded those of the controls. This difference was accounted for by an increase in T1 values in the frontal white matter of unipolar patients: the values for bipolar patients alone did not differ from those for controls. These preliminary findings support a hypothesis of frontal lobe dysfunction mediating pathological changes in mood.
对14例双相情感障碍患者、10例单相情感障碍患者以及一组相匹配的正常对照组进行了MRI T1质子弛豫值评估。患者额叶白质的T1值显著高于对照组。这种差异是由单相情感障碍患者额叶白质T1值升高所致：仅双相情感障碍患者的值与对照组无差异。这些初步发现支持了额叶功能障碍介导情绪病理变化这一假说。
