Steffens D C, Krishnan K R
Duke University Medical Center, Durham, North Carolina 27710, USA.
Biol Psychiatry. 1998 May 15;43(10):705-12. doi: 10.1016/s0006-3223(98)00084-5.
Neuroimaging is playing an increasing role in research of affective disorders, with investigators examining both volumetric changes of specific brain structures and vascular changes within white and gray matter. Recent studies have attempted to make clinical correlations between neuroimaging changes in unipolar and bipolar mood disorders. In this review, we focus particularly on those changes that are clinically meaningful. We conclude that there is enough evidence to begin to evaluate inclusion of neuroimaging findings in our mood disorder classification system. To this end, we propose two new mood disorder subtypes, vascular depression and vascular mania. Directions for future research in neuroimaging are then discussed.
神经影像学在情感障碍研究中发挥着越来越重要的作用，研究人员既在研究特定脑结构的体积变化，也在研究白质和灰质内的血管变化。最近的研究试图在单相和双相情感障碍的神经影像学变化之间建立临床关联。在这篇综述中，我们特别关注那些具有临床意义的变化。我们得出结论，有足够的证据开始评估将神经影像学结果纳入我们的情感障碍分类系统。为此，我们提出了两种新的情感障碍亚型，即血管性抑郁症和血管性躁狂症。然后讨论了神经影像学未来的研究方向。
