Office of the Pro-Vice Chancellor, University of Western Sydney, Locked Bag 1797, Sydney, Penrith, 2751 NSW, Australia.
Exp Eye Res. 2013 Dec;117:28-38. doi: 10.1016/j.exer.2013.08.010. Epub 2013 Aug 22.
Tear film stability can be assessed via a number of tools designed for clinical as well as research purposes. These techniques can give us insights into the tear film, and allow assessment of conditions that can lead to dry eye symptoms, and in severe cases, to significant ocular surface damage and deterioration of vision. Understanding what drives tear film instability and its assessment is also crucial for evaluating existing and new therapies. This review examines various techniques that are used to assess tear film instability: evaluation of tear break-up time and non-invasive break-time; topographic and interferometric techniques; confocal microscopic methods; aberrometry; and visual function tests. It also describes possible contributions of different tear film components; namely meibomian lipids, ocular mucins and proteins, and factors such as age, contact lens wear, ocular surgery and environmental stimuli, that may influence tear film instability.
泪膜稳定性可以通过多种工具进行评估，这些工具既可以用于临床目的，也可以用于研究目的。这些技术可以让我们深入了解泪膜，并评估可能导致干眼症状的情况，在严重的情况下，还会导致眼表面严重损伤和视力恶化。了解是什么导致了泪膜不稳定以及如何评估它，对于评估现有和新疗法也至关重要。这篇综述检查了用于评估泪膜不稳定的各种技术：泪膜破裂时间和非侵入性破裂时间的评估；形貌学和干涉测量技术；共焦显微镜方法；像差测量；以及视觉功能测试。它还描述了不同泪膜成分的可能贡献；即睑板腺脂质、眼黏蛋白和蛋白质，以及年龄、隐形眼镜佩戴、眼部手术和环境刺激等因素，这些因素可能会影响泪膜不稳定。
