Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States.
Hum Immunol. 2013 Dec;74(12):1696-700. doi: 10.1016/j.humimm.2013.08.010. Epub 2013 Aug 21.
Our work aimed to examine the potential influence of variants in interleukin/interleukin receptors genes on high-risk (HR-HPV) HPV clearance. Clearance of genital HR-HPV infection was evaluated for 134 HIV-1 seropositive African-American female adolescents from the Reaching for Excellence in Adolescent Care and Health (REACH) cohort. Genotyping targeted 225 single nucleotide polymorphisms (SNPs) within the exons, 5' untranslated region (UTR) and 3' UTR sequences of 27 immune-related candidate genes encoding interleukin family of cytokines. Cox proportional hazard models were used to determine the association of type-specific HPV clearance adjusting for time-varying CD4+ T-cell count and low-risk (LR-HPV) HPV co-infections. HR-HPV clearance rates were significantly (p < 0.001) associated with five SNPs (rs228942, rs419598, rs315950, rs7737000, and rs9292618) mapped to coding and regulatory regions in three genes (IL2RB, IL1RN, and IL7R). These data suggest that the analyzed genetic variants in interleukin family of cytokines modulate HR-HPV clearance in HIV-1 seropositive African-Americans that warrants replication.
我们的工作旨在研究白细胞介素/白细胞介素受体基因变异对高危（HR-HPV）HPV 清除的潜在影响。对来自 REACH 队列的 134 名 HIV-1 血清阳性的非裔美国青春期女性青少年进行了生殖器 HR-HPV 感染清除情况评估。基因分型针对 27 个免疫相关候选基因的外显子、5'非翻译区（UTR）和 3'UTR 序列中的 225 个单核苷酸多态性（SNP）进行靶向，这些基因编码白细胞介素家族细胞因子。Cox 比例风险模型用于确定特定类型 HPV 清除与时间变化的 CD4+T 细胞计数和低风险（LR-HPV）HPV 合并感染的关联。HR-HPV 清除率与五个 SNP（rs228942、rs419598、rs315950、rs7737000 和 rs9292618）显著相关（p<0.001），这些 SNP 映射到三个基因（IL2RB、IL1RN 和 IL7R）的编码和调控区域。这些数据表明，白细胞介素家族细胞因子分析的遗传变异调节了 HIV-1 血清阳性非裔美国人的 HR-HPV 清除，值得进一步研究。
