Institute of Human Virology at the University of Maryland School of Medicine, Baltimore, Maryland, USA.
Clin Transl Sci. 2011 Aug;4(4):282-4. doi: 10.1111/j.1752-8062.2011.00307.x.
HIV-1 natural viral suppressors (NVS) are individuals that control HIV replication without antiretrovirals (also know as HIV elite controllers). We have recently shown that these individuals have an elevated rate of hepatitis C virus (HCV) clearance. Given the association of IL28B genotype, specifically the rs12979860 single nucleotide polymorphism (SNP) based CC genotype, with HCV clearance, we studied its association with HIV control in 172 African American HIV subjects and 173 race-matched controls.
The frequency of the CC genotype was 12.5% in the NVS, 14.7% in the LVL ("low viral load" cohort with 400-20,000 HIV-1 RNA copies/mL), 17.8% in the MHVL ("medium/high viral load" cohort with >20,000 HIV-1 RNA copies/mL), and 11.6% in an HIV-negative cohort. There was no statistical significance in the CC genotype distribution between these cohorts (p= 0.48 between the NVS and non-NVS HIV positive controls, p= 0.85 between NVS and HIV-negatives). We also did not observe any association between CC genotype distribution and HIV RNA viral load, as a continuous measure.
The IL28B CC genotype does not account for the noted HIV control in our specific NVS cohort. Further studies will be needed to determine if a common genetic factor can primarily account for any joint clearance of HCV and control of HIV.
HIV-1 天然病毒抑制剂（NVS）是指无需抗逆转录病毒药物（也称为 HIV 精英控制者）即可控制 HIV 复制的个体。我们最近发现，这些个体具有更高的丙型肝炎病毒（HCV）清除率。鉴于白细胞介素 28B 基因型（特别是 rs12979860 单核苷酸多态性（SNP）的 CC 基因型）与 HCV 清除相关，我们研究了其与 172 名非裔美国 HIV 受试者和 173 名种族匹配对照者中 HIV 控制的关联。
NVS 中 CC 基因型的频率为 12.5%，低病毒载量（HIV-1 RNA 拷贝/mL 为 400-20,000）组为 14.7%，中/高病毒载量（HIV-1 RNA 拷贝/mL 为 >20,000）组为 17.8%，HIV 阴性组为 11.6%。这些队列之间的 CC 基因型分布没有统计学意义（NVS 与非 NVS HIV 阳性对照组之间 p=0.48，NVS 与 HIV 阴性组之间 p=0.85）。我们也没有观察到 CC 基因型分布与 HIV RNA 病毒载量之间的任何关联，作为连续测量。
IL28B CC 基因型不能解释我们特定 NVS 队列中观察到的 HIV 控制。需要进一步研究以确定是否存在共同的遗传因素主要导致 HCV 和 HIV 同时清除。
