ANZAC Research Institute, Gate 3 Hospital Road Concord RG Hospital, Concord, NSW 2139, Australia.
J Gerontol A Biol Sci Med Sci. 2014 May;69(5):514-8. doi: 10.1093/gerona/glt124. Epub 2013 Aug 23.
Age-related pseudocapillarization of the liver sinusoidal endothelium is associated with impaired lipid and drug metabolism and the development of disease. 2,5-Dimethoxy-4-iodoamphetamine is a serotonin receptor 2 agonist that has been shown to have beneficial effects on the liver sinusoidal endothelium in the setting of partial hepatectomy. Here, we have assessed whether 2,5-dimethoxy-4-iodoamphetamine influences ultrastructure of the sinusoidal endothelium in normal 7- and 24-month-old C57Bl6 mice. Following 48 hours of 2,5-dimethoxy-4-iodoamphetamine administration, we found that the liver endothelium in the young, but not in the old, mice had increased porosity compared with controls. This effect appeared to be modulated by increased fenestration size rather than a change in fenestration number. 2,5-Dimethoxy-4-iodoamphetamine is a useful manipulator of fenestration size in the young liver and could be harnessed in the search for therapeutic interventions for pseudocapillarization.
年龄相关性肝窦内皮伪毛细血管化与脂质和药物代谢受损以及疾病的发生发展有关。2,5-二甲氧基-4-碘苯丙胺是一种 5-羟色胺受体 2 激动剂，已被证明在部分肝切除的情况下对肝窦内皮有有益的影响。在这里，我们评估了 2,5-二甲氧基-4-碘苯丙胺是否会影响正常 7 个月和 24 个月大的 C57Bl6 小鼠的窦内皮超微结构。在给予 2,5-二甲氧基-4-碘苯丙胺 48 小时后，我们发现年轻小鼠的肝内皮与对照组相比具有更高的通透性，而老年小鼠则没有。这种作用似乎是通过增加窗孔大小而不是改变窗孔数量来调节的。2,5-二甲氧基-4-碘苯丙胺是年轻肝脏中调节窗孔大小的有效手段，可用于寻找治疗伪毛细血管化的治疗干预措施。
