Uranium deposition in bones of Wistar rats associated with skeleton development.

作者信息

Rodrigues G, Arruda-Neto J D T, Pereira R M R, Kleeb S R, Geraldo L P, Primi M C, Takayama L, Rodrigues T E, Cavalcante G T, Genofre G C, Semmler R, Nogueira G P, Fontes E M

机构信息

Physics Institute University of São Paulo, São Paulo-SP, Brazil; Veterinary Medicine School, Methodist University, São Paulo-SP, Brazil.

出版信息

Appl Radiat Isot. 2013 Dec;82:105-10. doi: 10.1016/j.apradiso.2013.07.033. Epub 2013 Aug 7.

DOI:10.1016/j.apradiso.2013.07.033

PMID:23974305

Abstract

Sixty female Wistar rats were submitted to a daily intake of ration doped with uranium from weaning to adulthood. Uranium in bone was quantified by the SSNTD (solid state nuclear track detection) technique, and bone mineral density (BMD) analysis performed. Uranium concentration as a function of age exhibited a sharp rise during the first week of the experiment and a drastic drop of 70% in the following weeks. Data interpretation indicates that uranium mimics calcium. Results from BMD suggest that radiation emitted by the incorporated Uranium could induce death of bone cells.

摘要