Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy.
Curr Opin Allergy Clin Immunol. 2013 Oct;13(5):558-62. doi: 10.1097/ACI.0b013e328364ec7a.
The purpose of the present review is to provide an overview on the clinical features and long-term complications of severe ocular allergies, with a special focus on the corneal involvement observed in these diseases, which may impair vision permanently. Furthermore, different treatment options are discussed based on the sight-threatening effects of corticosteroid use.
Recent data on the demographics, clinical and immunologic features of vernal and atopic keratoconjunctivitis are presented and discussed, and the evidence of a lack of literature addressing the issue of visual outcome in allergic diseases is underlined. The efficacy and possible long-term complications of their treatments are described, including visual impairment.
Diagnosis and treatment of patients with severe ocular allergy is a challenge for ophthalmologists due to the long-term corneal complications and the potential side-effects of topical corticosteroids that may induce cataract formation and glaucoma, and impair vision permanently. The review describes old and new concepts of management and possible complications such as severe, vision-threatening forms of allergic ocular disease. An update on their management and long-term complications may help clinicians to establish a common agreement on treatment options and researchers to design future studies based on similar outcomes, including visual acuity.
本综述的目的是概述严重眼部过敏的临床特征和长期并发症,特别关注这些疾病中观察到的角膜受累,这可能会导致永久性视力损害。此外,还根据皮质类固醇使用对视功能威胁的影响讨论了不同的治疗选择。
介绍和讨论了春季和特应性角结膜炎的人口统计学、临床和免疫学特征的最新数据,并强调了缺乏关于过敏疾病视觉结果的文献。描述了它们治疗的疗效和可能的长期并发症,包括视力障碍。
由于长期的角膜并发症和局部皮质类固醇可能引起白内障和青光眼,并永久性损害视力的潜在副作用,严重眼部过敏患者的诊断和治疗对眼科医生来说是一个挑战。该综述描述了管理和可能的并发症的旧概念和新概念,如严重的、对视功能有威胁的过敏性眼病。对其管理和长期并发症的更新可能有助于临床医生就治疗选择达成共识,并帮助研究人员根据包括视力在内的类似结果设计未来的研究。