Bonini Stefano, Sacchetti Marta, Mantelli Flavio, Lambiase Alessandro
Department of Ophthalmology, University of Rome Campus Bio-Medico, Rome, Italy.
Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):436-41. doi: 10.1097/ACI.0b013e3282efb726.
The purpose of the present review is to provide an overview on the clinical features of vernal keratoconjunctivitis on the basis of cases series presented in the literature. Furthermore, a new grading system of vernal keratoconjunctivitis based on the severity of the disease is proposed. Different treatment options are discussed based on the clinical grade of vernal keratoconjunctivitis.
Recent epidemiological studies on the demographic, clinical and immunologic features of vernal keratoconjunctivitis are presented. The efficacy and complications of treatments are described.
Diagnosis and treatment of patients is a challenge for ophthalmologists as no precise diagnostic criteria have been established, the pathogenesis is unclear, and antiallergic treatments are often unsuccessful. This review describes old and new concepts of vernal keratoconjunctivitis diagnosis and treatment: the clinical features, the diagnostic criteria, the common features between this and other ocular allergies and the therapeutic strategies. On the basis of this knowledge, a new grading system is introduced based on clinical signs and symptoms of ocular surface inflammation. This new grading of vernal keratoconjunctivitis may help clinicians and researchers to classify disease activity and to establish a common agreement for treatments.
本综述旨在基于文献中呈现的病例系列，对春季角结膜炎的临床特征进行概述。此外，提出一种基于疾病严重程度的春季角结膜炎新分级系统。并根据春季角结膜炎的临床分级讨论不同的治疗选择。
介绍了近期关于春季角结膜炎的人口统计学、临床和免疫学特征的流行病学研究。描述了治疗的疗效和并发症。
由于尚未确立精确的诊断标准、发病机制尚不清楚且抗过敏治疗往往不成功，因此对患者的诊断和治疗对眼科医生而言是一项挑战。本综述描述了春季角结膜炎诊断和治疗的新旧概念：临床特征、诊断标准、与其他眼部过敏的共同特征以及治疗策略。基于这些知识，引入了一种基于眼表炎症临床体征和症状的新分级系统。这种春季角结膜炎的新分级可能有助于临床医生和研究人员对疾病活动进行分类，并就治疗达成共识。
