Tien H F, Lee F Y, Chuang S M, Lin C T
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Cancer Genet Cytogenet. 1990 Oct 1;49(1):31-6. doi: 10.1016/0165-4608(90)90161-3.
Cytogenetic results of a nasopharyngeal carcinoma (NPC) cell line NPC-TW039 and its subline NPC-TW039-N1, established from the nude mouse transplant, were reported. This is the third case of NPC presented with banded karyotype, to date, in the literature. A 3q + marker chromosome, with involvement of band q25 similar to that present in the two previously reported cases, was detected in most tumor cells from both cell lines. The structural chromosome abnormalities of NPC-TW039-N1 were similar to its original cell line, NPC-TW039, except that the subline lost one marker chromosome and gained a new one.
报道了一种鼻咽癌（NPC）细胞系NPC-TW039及其从裸鼠移植瘤建立的亚系NPC-TW039-N1的细胞遗传学结果。这是文献中迄今为止第三例呈现带型核型的鼻咽癌病例。在这两种细胞系的大多数肿瘤细胞中均检测到一条3q +标记染色体，其q25带的受累情况与之前报道的两例相似。NPC-TW039-N1的染色体结构异常与其原始细胞系NPC-TW039相似，只是该亚系丢失了一条标记染色体并获得了一条新的。
