Sizhong Z, Xiukung G, Yi Z
Int J Cancer. 1983 May 15;31(5):587-90. doi: 10.1002/ijc.2910310509.
An epithelial cell line, CNE-2, has been recently established from a poorly differentiated nasopharyngeal carcinoma, and it represents the first of its kind. Using chromosome banding techniques, cytogenetic analysis of the cell line was carried out. It was demonstrated that the chromosome numbers of the CNE-2 cells varied from 87 to 107 and the modal number was 104-103. All cells contained a series of structurally abnormal chromosomes, and most of them were either consistent or frequently found. Among these chromosomes there were two giant markers which, by banding pattern analysis, proved to be distinct from the so-called giant group A marker chromosomes previously found in many lymphoblastoid cell lines from NPC. Comparison between the CNE-2 and CNE, another epithelial cell line, which was established from well-differentiated squamous NPC, showed that while they were quite different in many cytogenetic aspects, they had three marker chromosomes in common, namely, an iso8q, a t(?;3q) and a small acrocentric one. The question of whether chromosome markers specific for NPC exist is discussed in the light of the data presented.
一种上皮细胞系CNE - 2最近从低分化鼻咽癌中建立起来，它是同类中的首个细胞系。利用染色体显带技术，对该细胞系进行了细胞遗传学分析。结果表明，CNE - 2细胞的染色体数目在87至107之间变化，众数为104 - 103。所有细胞都含有一系列结构异常的染色体，其中大多数染色体是一致的或经常出现的。在这些染色体中有两个巨大标记，通过显带模式分析，证明它们与先前在许多来自鼻咽癌的淋巴母细胞系中发现的所谓巨大A组标记染色体不同。将CNE - 2与另一种上皮细胞系CNE进行比较，后者是从高分化鳞状鼻咽癌中建立的，结果表明，虽然它们在许多细胞遗传学方面有很大差异，但它们有三条共同的标记染色体，即一条等臂8号染色体、一条t(?;3q)染色体和一条小的近端着丝粒染色体。根据所提供的数据，讨论了是否存在鼻咽癌特异性染色体标记的问题。
