Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan. matsumoto−
Allergol Int. 2013 Sep;62(3):291-6. doi: 10.2332/allergolint.13-RAI-0603.
Results from recent epidemiological studies strongly suggest that ingestion of food promotes immune tolerance to food antigens, whereas exposure to food antigens through skin leads to allergic sensitization. A "dual-allergen-exposure hypothesis" has been proposed to explain those findings. However, several other recent studies have demonstrated that some allergic diseases can be successfully treated by recurrent epicutaneous exposure to allergens. At a glance, these two sets of findings seem to be contradictory, but we think they provide important clues for understanding the mechanisms behind the allergy march. Here, we propose that per-"eczema"tous sensitization drives the allergy march, and we introduce results from several published studies in support of this hypothesis. We hope that this review may help in establishment of new strategies for preventing the allergy march in the near future.
最近的流行病学研究结果强烈表明，食物的摄入会促进对食物抗原的免疫耐受，而通过皮肤接触食物抗原则会导致过敏致敏。人们提出了“双抗原暴露假说”来解释这些发现。然而，最近的其他几项研究表明，一些过敏性疾病可以通过反复进行过敏原的经皮暴露来成功治疗。乍一看，这两组发现似乎相互矛盾，但我们认为它们为理解过敏进程背后的机制提供了重要线索。在这里，我们提出，持续的致敏会推动过敏进程，并介绍了一些已发表的研究结果来支持这一假说。我们希望这篇综述可以帮助我们在不久的将来制定预防过敏进程的新策略。
