Drexel University College of Medicine, Department of Neurology, Philadelphia, PA, USA.
Headache. 2010 Apr;50(4):631-48. doi: 10.1111/j.1526-4610.2009.01554.x. Epub 2009 Oct 21.
Adipose tissue is a dynamic neuroendocrine organ that is involved in multiple physiological and pathological processes, and when excessive, results in obesity. Clinical and population-based data suggest that migraine and chronic daily headache are associated with obesity, as estimated by anthropometric indices. In addition, translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. In this article, we first review the definition and ascertainment of obesity. This is followed by a review of the clinical and population-based studies evaluating the associations between obesity and chronic daily headache and migraine. We then discuss the central and peripheral pathways involved in the regulation of feeding, where it overlaps with migraine pathophysiology, and where future research may be headed in light of these data.
脂肪组织是一个动态的神经内分泌器官，参与多种生理和病理过程，当脂肪组织过度时，会导致肥胖。临床和基于人群的研究表明，偏头痛和慢性每日头痛与肥胖有关，肥胖可以通过人体测量指数来估计。此外，转化和基础科学研究表明，偏头痛病理生理学和调节进食的中枢和外周途径之间存在多个重叠领域。具体而言，神经递质如血清素、肽如食欲素以及脂肪细胞因子如脂联素和瘦素被认为在进食和偏头痛中都有作用。在本文中，我们首先回顾了肥胖的定义和确定方法。接下来，我们回顾了评估肥胖与慢性每日头痛和偏头痛之间关联的临床和基于人群的研究。然后，我们讨论了参与进食调节的中枢和外周途径，其中与偏头痛病理生理学有重叠之处，以及根据这些数据未来研究可能的方向。
