Istituto Dermopatico del'Immacolata-IRCCS, Vascular Pathology Laboratory, Via dei Monti di Creta 104, Rome 00167, Italy.
Int J Mol Sci. 2013 Aug 22;14(9):17319-46. doi: 10.3390/ijms140917319.
Oxidative stress has been demonstrated to play a causal role in different vascular diseases, such as hypertension, diabetic vasculopathy, hypercholesterolemia and atherosclerosis. Indeed, increased reactive oxygen species (ROS) production is known to impair endothelial and vascular smooth muscle cell functions, contributing to the development of cardiovascular diseases. MicroRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of target messenger RNAs. They have been shown to be modulated in most biological processes, including in cellular responses to redox imbalance. In particular, miR-200 family members play a crucial role in oxidative-stress dependent endothelial dysfunction, as well as in cardiovascular complications of diabetes and obesity. In addition, different miRNAs, such as miR-210, have been demonstrated to play a key role in mitochondrial metabolism, therefore modulating ROS production and sensitivity. In this review, we will discuss miRNAs modulated by ROS or involved in ROS production, and implicated in vascular diseases in which redox imbalance has a pathogenetic role.
氧化应激被证明在不同的血管疾病中起因果作用，如高血压、糖尿病血管病变、高胆固醇血症和动脉粥样硬化。事实上，已知增加的活性氧（ROS）的产生会损害内皮和血管平滑肌细胞的功能，导致心血管疾病的发展。microRNAs（miRNAs）是调节靶信使 RNA 的稳定性和/或翻译效率的非编码 RNA 分子。它们已被证明在大多数生物过程中被调节，包括细胞对氧化还原失衡的反应。特别是，miR-200 家族成员在依赖氧化应激的内皮功能障碍以及糖尿病和肥胖症的心血管并发症中发挥着关键作用。此外，不同的 miRNAs，如 miR-210，已被证明在调节 ROS 产生和敏感性的线粒体代谢中发挥关键作用。在这篇综述中，我们将讨论 ROS 调节或参与 ROS 产生的 miRNAs，并讨论它们在氧化还原失衡具有发病作用的血管疾病中的作用。
