Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, DE-49076 Osnabrück, Germany.
Acta Derm Venereol. 2013 Nov;93(6):644-9. doi: 10.2340/00015555-1677.
Acne appears to represent a visible indicator disease of over-activated mTORC1 signalling, an unfavour-able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and insulin resistance. Exaggerated mTORC1 signalling by Western diet explains the association of acne with increased body mass index, insulin resistance, and early onset of menarche. Both, a high glycaemic load and increased consumption of milk and milk products, staples of Western diet, aggravate mammalian target of rapamycin complex 1 signalling. This review of the literature summarises present evidence for an association between acne, increased body mass index, insulin resistance and Western diet. By dietary intervention with a Palaeolithic-type diet, the dermatologist has the chance to attenuate patients' increased mTORC1 signalling by reducing glycaemic load and milk consumption, which may not only improve acne but may delay the march to more serious mTORC1-driven diseases of civilisation.
痤疮似乎代表了一种可见的指标性疾病，即 mTORC1 信号过度激活，这是一种代谢偏差，预示着容易患上与体重指数增加和胰岛素抵抗相关的严重西方文明病。西方饮食中 mTORC1 信号的过度激活解释了痤疮与体重指数增加、胰岛素抵抗和初潮提前的关联。高血糖负荷和增加牛奶及奶制品的摄入（西方饮食的主食）都会加重雷帕霉素哺乳动物靶标复合物 1 信号。本文对文献进行综述，总结了痤疮、体重指数增加、胰岛素抵抗与西方饮食之间的关联。皮肤科医生可以通过采用旧石器时代饮食进行饮食干预，降低血糖负荷和牛奶摄入量，从而减轻患者 mTORC1 信号的过度激活，这不仅可以改善痤疮，还可能延缓向更严重的、由 mTORC1 驱动的文明病发展。
