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[半夏对小鼠骨髓嗜多染红细胞（PCE）微核发生及人培养淋巴细胞姐妹染色单体交换频率的影响]

[Influence of Rhizoma pinelliae on the occurrence of micronucleus in bone marrow polychromatic erythrocytes (PCE) in mice and frequencies of SCE in cultured human lymphocytes].

作者信息

Yang S, He M

机构信息

Institute of Chinese Materia Medica, China Academy of TCM, Beijing.

出版信息

Zhong Xi Yi Jie He Za Zhi. 1990 Jun;10(6):356-8, 326.

PMID:2397557
Abstract

Contradictory effects of Rhizoma Pinelliae have been reported in pregnant mice, rats and rabbits, because the decoction of Rhizoma Pinelliae has obvious embryotoxicity. This paper was obtain an experimental analysis of the frequencies of micronucleus of bone marrow polychromatic erythrocytes (PCE) in mice and sister chromatid exchange (SCE) in cultural lymphocytes of human. The results showed that the decoction of Rhizoma Pinelliae neither induces the occurrencies of micronucleus nor SCE frequencies. Therefore, it may be concluded that the decoction does not have toxicogenetical effects.

摘要

据报道，半夏对怀孕的小鼠、大鼠和兔子有相反的作用，因为半夏水煎剂具有明显的胚胎毒性。本文旨在对小鼠骨髓嗜多染红细胞（PCE）微核频率和人类培养淋巴细胞姐妹染色单体交换（SCE）进行实验分析。结果表明，半夏水煎剂既不诱导微核的出现，也不影响SCE频率。因此，可以得出结论，该水煎剂没有遗传毒性作用。

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