Perm State Medical Academy, Perm, Russian Federation.
Diab Vasc Dis Res. 2013 Nov;10(6):489-97. doi: 10.1177/1479164113494881. Epub 2013 Aug 22.
The objective of this study is to explore changes in microvascular tone during a contralateral cold pressor test and to compare the results obtained in healthy subjects and in patients with impaired glucose tolerance (IGT) and type 2 diabetes. Low-amplitude fluctuations of skin temperature in the appropriate frequency ranges were used as a characteristic for the mechanism for vascular tone regulation. In total, 13 adults with type 2 diabetes aged 40-67 years and 18 adults with IGT aged 31-60 years participated in this pilot study. The control group included 12 healthy men and women aged 39-60 years. The response to the cold pressor test in patients with type 2 diabetes and with IGT differs essentially from that of healthy subjects in the endothelial frequency range. Endothelial dysfunction occurs in the preclinical stage of diabetes and manifests, in particular, as a disturbance of the endothelial part of vascular tone regulation.
本研究旨在探讨在对侧冷加压试验期间微血管张力的变化，并比较健康受试者以及糖耐量受损（IGT）和 2 型糖尿病患者的结果。皮肤温度的小振幅波动在适当的频率范围内被用作血管张力调节机制的特征。共有 13 名年龄在 40-67 岁的 2 型糖尿病成年人和 18 名年龄在 31-60 岁的 IGT 成年人参加了这项初步研究。对照组包括 12 名年龄在 39-60 岁的健康男性和女性。2 型糖尿病患者和 IGT 患者对冷加压试验的反应与健康受试者在内皮细胞频率范围内的反应有本质上的不同。内皮功能障碍发生在糖尿病的临床前期，主要表现为血管张力调节的内皮部分紊乱。
