Jay V, Chan F W, Becker L E
Division of Neuropathology (Department of Pathology), Hospital for Sick Children, Toronto, Ont., Canada.
Brain Res Dev Brain Res. 1990 Jul 1;54(2):291-4. doi: 10.1016/0165-3806(90)90153-p.
Dendritic arborization patterns of visual cortical neurons in four cases of trisomy 18 syndrome were compared with those in 8 neurologically asymptomatic age-matched controls. The trisomy cases included a 20-week-old fetus, a term infant, a 3-month-old infant, and 6-month-old infant. Quantitative Golgi analysis showed a decrease in the mean total dendritic length of apical dendrites in layer 5 pyramidal neurons in the term infant with trisomy 18. In layer 3, an attenuated dendritic tree was observed in the earlier age groups with increased dendritic extent at 6 months. Although not conclusive, due to the small number of subjects, this preliminary study showed definitive dendritic abnormalities in the trisomy 18 syndrome.
将18三体综合征4例患者视觉皮层神经元的树突分支模式与8例年龄匹配、无神经症状的对照者进行了比较。三体综合征病例包括一名20周龄胎儿、一名足月儿、一名3月龄婴儿和一名6月龄婴儿。定量高尔基分析显示，18三体综合征足月儿第5层锥体神经元顶树突的平均总树突长度减少。在第3层，在较早年龄组观察到树突树变细，6个月时树突范围增加。尽管由于研究对象数量较少，结果尚无定论，但这项初步研究显示18三体综合征存在明确的树突异常。
