Sallì L, Scalici G, Corrao S, Curiale B, Salerno L
Institute of Clinical Medicine, University of Palermo, Italy.
Clin Exp Rheumatol. 1990 Jul-Aug;8(4):397-400.
Our investigation included 20 patients with rheumatoid arthritis and a negative routine (albustix) proteinuria test, and 20 healthy controls. The albustix test was compared with a method based on multifractional Cellogel RS electrophoresis of urinary proteins. The albustix test was found to be not reliable in patients with RA. Microproteinuria was in fact detected by the electrophoresis method in 12 out of 20 RA patients. Eleven patients showed glomerular type proteinuria (which was "selective" in 5 patients and "non-selective" in 6 patients), and 1 patient showed mixed type proteinuria. Electrophoresis failed to show microproteinuria in the controls. The high sensitivity, easy handling and low cost of multifractioned electrophoresis (which does not involve disturbing the patients) suggest its introduction as a routine test for all RA patients, thus achieving both accurate clinical assessment of proteinuria and a rational therapeutic approach.
我们的研究纳入了20例类风湿性关节炎患者，其常规（尿蛋白试纸）蛋白尿检测结果为阴性，以及20名健康对照者。将尿蛋白试纸检测与基于尿蛋白多组分Cellogel RS电泳的方法进行比较。发现尿蛋白试纸检测在类风湿性关节炎患者中不可靠。事实上，通过电泳法在20例类风湿性关节炎患者中的12例检测到了微量蛋白尿。11例患者表现为肾小球型蛋白尿（其中5例为“选择性”，6例为“非选择性”），1例患者表现为混合型蛋白尿。对照组电泳未显示微量蛋白尿。多组分电泳具有高灵敏度、操作简便和成本低（不干扰患者）的特点，建议将其作为所有类风湿性关节炎患者的常规检测方法，从而实现蛋白尿的准确临床评估和合理的治疗方法。
