铁卤化物介导的末端炔烃与磺酰基腙的区域和立体选择性卤代磺酰化反应：（E）-β-氯和溴代乙烯砜的合成。
Iron halide-mediated regio- and stereoselective halosulfonylation of terminal alkynes with sulfonylhydrazides: synthesis of (E)-β-chloro and bromo vinylsulfones.
机构信息
College of Chemical Engineering and Materials Science, Zhejiang University of Technology , Hangzhou 310014, People's Republic of China.
出版信息
J Org Chem. 2013 Sep 20;78(18):9499-504. doi: 10.1021/jo401581n. Epub 2013 Sep 11.
PMID:23978040
Abstract
Halosulfonylation of terminal alkynes was achieved with sulfonylhydrazides as the sulfonyl precursor and inexpensive iron halide as halide source in the presence of TBHP, allowing the regio- and stereoselective generation of (E)-β-chloro and bromo vinylsulfones.
摘要
末端炔烃的卤磺酰化反应是在 TBHP 的存在下，以磺酰肼作为磺酰前体，廉价的铁卤化物作为卤源来实现的，这允许（E）-β-氯和溴代乙烯基砜进行区域和立体选择性的生成。
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