Zhang Yujun, Vessally Esmail
School of Chemistry and Environmental Engineering, Hanshan Normal University Chaozhou 521041 Guangdong P. R. China
Department of Chemistry, Payame Noor University P.O. Box 19395-3697 Tehran Iran.
RSC Adv. 2021 Oct 13;11(53):33447-33460. doi: 10.1039/d1ra03443j. eCollection 2021 Oct 8.
The difunctionalization reactions of easily available and inexpensive alkynes have emerged as a reliable, powerful, and step-economical approach for the construction of highly substituted complex alkenes in a one-pot manner, without the need for isolation of intermediates. A wide variety of transformations based on this concept have been successfully achieved for the preparation of synthetically and biologically important β-halovinyl sulfone scaffolds. In this Review, we summarize the recent advances and developments in this field and present a comprehensive overview of halosulfonylation of alkyne substrates with emphasis on the mechanistic features of the reactions.
易得且廉价的炔烃的双官能化反应已成为一种可靠、强大且步骤经济的方法，可通过一锅法构建高度取代的复杂烯烃，无需分离中间体。基于这一概念的各种转化已成功实现，用于制备具有合成和生物学重要性的β-卤代乙烯基砜支架。在本综述中，我们总结了该领域的最新进展和发展，并全面概述了炔烃底物的卤代磺酰化反应，重点介绍了反应的机理特征。
