Fernandez-Bustamante Ana, Repine John E
University of Colorado SOM, Dept. of Anesthesiology & Webb-Waring Center, 12631 E 17th Ave, AO-1, R2012, MS 8202, Aurora, CO, 80045, USA.
Curr Pharm Des. 2014;20(9):1400-8. doi: 10.2174/13816128113199990561.
The Acute Respiratory Distress Syndrome (ARDS) is a highly fatal pro-inflammatory oxidative respiratory disease. Relatively recently, the modulating effects of chronic inflammatory processes on ARDS susceptibility have been recognized in a number of clinical studies. Herein, we briefly review some of the chronic conditions that have been reported to increase (cigarette smoking and alcohol abuse) or decrease (diabetes and obesity) susceptibility to ARDS. We also propose some potential pathways that may hold clues regarding the pathogenesis and/or therapy for ARDS.
急性呼吸窘迫综合征（ARDS）是一种具有高度致死性的促炎性氧化呼吸疾病。相对较近的时候，一些临床研究已经认识到慢性炎症过程对ARDS易感性的调节作用。在此，我们简要回顾一些据报道会增加（吸烟和酗酒）或降低（糖尿病和肥胖）ARDS易感性的慢性疾病。我们还提出了一些可能为ARDS的发病机制和/或治疗提供线索的潜在途径。
