Toledo Jon B, Van Deerlin Vivianna M, Lee Edward B, Suh EunRan, Baek Young, Robinson John L, Xie Sharon X, McBride Jennifer, Wood Elisabeth M, Schuck Theresa, Irwin David J, Gross Rachel G, Hurtig Howard, McCluskey Leo, Elman Lauren, Karlawish Jason, Schellenberg Gerard, Chen-Plotkin Alice, Wolk David, Grossman Murray, Arnold Steven E, Shaw Leslie M, Lee Virginia M-Y, Trojanowski John Q
Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alzheimers Dement. 2014 Jul;10(4):477-484.e1. doi: 10.1016/j.jalz.2013.06.003. Epub 2013 Aug 24.
Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new diseases, formulating staging schemes, and establishing correlations between neuropathological changes and clinical features. However, brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples. Moreover, the value of biobanks is greatly enhanced if they link all the multidimensional clinical and laboratory information of each case, which is accomplished, optimally, using systematic and standardized operating procedures, and in the framework of multidisciplinary teams with the support of a flexible and user-friendly database system that facilitates the sharing of information of all the teams in the network. We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania.
神经退行性疾病（NDs）的定义是中枢神经系统（CNS）中异常蛋白质沉积物的积累，只有神经病理学检查才能做出明确诊断。脑库及其相关科学项目塑造了我们对NDs的实际认知，识别并表征了定义新疾病的CNS沉积物，制定了分期方案，并建立了神经病理学变化与临床特征之间的关联。然而，脑库已经发展到能够保存生物流体以及DNA和RNA样本。此外，如果生物样本库将每个病例的所有多维度临床和实验室信息联系起来，其价值将大大提高，这最好通过系统和标准化的操作程序来实现，并在多学科团队的框架内，借助灵活且用户友好的数据库系统的支持，该系统便于网络中所有团队共享信息。我们描述了一个生物样本库系统，它是宾夕法尼亚大学神经退行性疾病研究中心进行探索性研究的平台。
