Varghese Thomas, Ahmed Riaz, Sankaran Jayaram D, Al-Khusaiby Saleh M
Department of Child Health, The Royal Hospital, PO Box 1331, P.C. 111, Seeb CPO, Sultanate of Oman. Tel. +968 593667. Fax. +968 699869. E-mail:
Neurosciences (Riyadh). 2002 Oct;7(4):293-5.
Myasthenia gravis is a disorder of impaired neuromuscular transmission resulting in weakness and abnormal fatigability on exertion, improved by anti-acetyl cholinesterase drugs. A number of drugs are known to exacerbate myasthenia gravis or interfere with neuromuscular transmission. We report a case of D-penicillamine induced myasthenia gravis who developed ptosis, diplopia and easy fatigability, 4 years after initiation of the drug for Wilson`s disease. On stopping the drug, within 3 months all her symptoms disappeared without any anti-acetyl cholinesterase drugs. Thus, the onset of drug induced myasthenia gravis could be insidious but the withdrawal of the drug leads to rapid recovery.
重症肌无力是一种神经肌肉传递受损的疾病，导致用力时出现无力和异常疲劳，抗乙酰胆碱酯酶药物可改善症状。已知多种药物会加重重症肌无力或干扰神经肌肉传递。我们报告一例由青霉胺诱发的重症肌无力病例，患者在开始使用该药治疗威尔逊病4年后出现上睑下垂、复视和易疲劳症状。停药后，在3个月内她所有症状未使用任何抗乙酰胆碱酯酶药物便消失了。因此，药物诱发的重症肌无力起病可能隐匿，但停药后可迅速恢复。
