凋亡磷脂酰丝氨酸暴露的机制。
Mechanisms of apoptotic phosphatidylserine exposure.
机构信息
1] INSERM, U848, F-94805 Villejuif, France [2] Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.
出版信息
Cell Res. 2013 Nov;23(11):1247-8. doi: 10.1038/cr.2013.115. Epub 2013 Aug 27.
Abstract
It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.
摘要
一直以来，哪种 scramblase 会导致凋亡细胞表面暴露磷脂酰丝氨酸残基，从而促进吞噬细胞对凋亡细胞尸体的识别、吞噬和破坏，这是一个长期存在的谜。在最近发表在《科学》杂志上的一篇论文中，Nagata 及其同事揭示了 scramblases Xkr8 和其在秀丽隐杆线虫中的同源物 CED-8，在凋亡细胞中通过半胱天冬酶切割而被激活。
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本文引用的文献
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