采用超快速萃取和多维高效亲和色谱法分析手性药物的游离分数。
Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography.
机构信息
Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.
出版信息
Analyst. 2013 Nov 7;138(21):6262-5. doi: 10.1039/c3an01315d.
Abstract
A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.
摘要
建立了一种多维色谱方法来测量同时含有结合蛋白或血清的样品中药物对映体的游离分数。该方法结合了超快速亲和萃取和手性固定相，并用药物华法林和蛋白质人血清白蛋白进行了验证。
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