Kovacic P, Kassel M A, Castonguay A, Kem W R, Feinberg B A
Department of Chemistry, University of Wisconsin-Milwaukee 53201.
Free Radic Res Commun. 1990;10(3):185-92. doi: 10.3109/10715769009149887.
Cyclic voltammetry data were obtained for a number of biologically active compounds which incorporate imine substitution on the pyridine nucleus. The reductions in acid (iminium ion formation) were for the most part reversible, and in the range of -0.5 to -0.7V. The toxic effect of these drugs is thought to be caused by the generation of reactive oxygen radicals that arise via charge transfer, or by disruption of electron transport chains.
获得了许多在吡啶环上含有亚胺取代基的生物活性化合物的循环伏安数据。在酸性条件下的还原反应（亚胺离子形成）大多是可逆的，电位范围在-0.5至-0.7V之间。这些药物的毒性作用被认为是由电荷转移产生的活性氧自由基或电子传递链的破坏所引起的。
