Institute of Pathology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany,
Virchows Arch. 2013 Nov;463(5):731-5. doi: 10.1007/s00428-013-1476-3. Epub 2013 Aug 25.
Somatic-type malignancy (STM), defined as any sarcoma, carcinoma, leukemia or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors. Neuroendocrine carcinoma developing in a mediastinal germ cell tumor has not been previously reported. We here describe a 22-year-old man who underwent resection of a 11-cm mediastinal teratoma which consisted of components of all three germ cell layers with prominent foci of fetal-like liver tissue. The liver areas were surrounded by primitive neuroendocrine structures with ductal and solid growth pattern with a high proliferation rate. We diagnosed an immature mediastinal teratoma with STM, specifically neuroendocrine carcinoma arising in a background of immature liver tissue. Comparative genomic hybridization of dissected tumor tissue revealed chromosomal gains at 12 in the teratoma and neuroendocrine carcinoma component. In summary, clinicians and pathologists should be aware of neuroendocrine carcinoma as a rare type of STM complicating mediastinal germ cell tumors.
体瘤（STM），定义为任何肉瘤、癌、白血病或淋巴瘤在生殖细胞瘤中发展，约占所有生殖细胞瘤的 2%。在纵隔生殖细胞瘤中发生的神经内分泌癌以前没有报道过。我们在此描述一名 22 岁男性，他接受了 11 厘米纵隔畸胎瘤的切除术，该肿瘤由所有三个生殖细胞层的成分组成，并有明显的胎儿样肝组织灶。肝区被原始神经内分泌结构包围，呈导管和实性生长模式，增殖率高。我们诊断为不成熟的纵隔畸胎瘤伴 STM，特别是在不成熟肝组织背景下发生的神经内分泌癌。解剖肿瘤组织的比较基因组杂交显示，畸胎瘤和神经内分泌癌成分中 12 号染色体增益。总之，临床医生和病理学家应该意识到神经内分泌癌是一种罕见类型的 STM，合并纵隔生殖细胞瘤。
