Agarwal Swati, Mullick Shalini, Gupta Kumud, Dewan Ravindra Kumar
Department of Pathology, National Institute of TB and Respiratory Disease, New Delhi, India.
Department of Thoracic Surgery, National Institute of TB and Respiratory Diseases, New Delhi, India.
Turk Thorac J. 2015 Apr;16(2):101-104. doi: 10.5152/ttd.2014.4280. Epub 2014 Nov 18.
Germ cell tumors constitute 10% to 15% of anterior mediastinal neoplasms. Of these, mature teratoma is the most common. Somatic malignant transformation in mature teratoma is a very rare phenomenon. In the anterior mediastinum, few cases of malignant transformation in the form of carcinoma, sarcoma, or neuroendocrine tumors have been described. We present the case of a mature mediastinal teratoma in a 24-year-old female, diagnosed on computed tomography, where both carcinoid tumor and adenocarcinoma were seen. To the best of our knowledge, this is the first report of such a case. Malignant transformation in a mature teratoma confers a significantly worse prognosis and is difficult to diagnose only on clinical and radiological evaluation. As these lesions are so rare, the treatment options for these lesions are also not clearly defined. Extensive sampling and careful microscopic examination are needed when teratomas are submitted for pathological evaluation.
生殖细胞肿瘤占前纵隔肿瘤的10%至15%。其中，成熟畸胎瘤最为常见。成熟畸胎瘤发生体细胞恶性转化是一种非常罕见的现象。在前纵隔，仅有少数以癌、肉瘤或神经内分泌肿瘤形式发生恶性转化的病例被报道。我们报告一例24岁女性的成熟纵隔畸胎瘤，通过计算机断层扫描诊断，其中同时发现了类癌肿瘤和腺癌。据我们所知，这是此类病例的首例报告。成熟畸胎瘤发生恶性转化会导致预后明显更差，且仅通过临床和影像学评估很难诊断。由于这些病变非常罕见，针对这些病变的治疗方案也尚未明确界定。当畸胎瘤进行病理评估时，需要进行广泛取材和仔细的显微镜检查。
