Department of Haematology, Central Pathology Laboratory, St. James's Hospital, Dublin 8, Ireland,
Med Oncol. 2013 Dec;30(4):692. doi: 10.1007/s12032-013-0692-7. Epub 2013 Aug 24.
Hairy cell leukaemia (HCL) and chronic lymphocytic leukaemia (CLL) are distinct clinicopathological B cell chronic lymphoproliferative disorders (B-CLPD). Both diseases have characteristic immunophenotypic and molecular features. The co-existence of two B-CLPD is perhaps more common than previously thought but a composite HCL and CLL has been rarely documented. A case is reported in which the morphology, integrated with an extensive immunophenotyping panel, and incorporation of the recently described HCL-associated BRAF V600E mutation, enabled the prompt diagnosis of composite HCL and CLL thus allowing appropriate treatment selection. This case serves to highlight the benefit of a multidisciplinary approach to the diagnosis of bi-clonal B-CLPD.
毛细胞白血病（HCL）和慢性淋巴细胞白血病（CLL）是两种不同的临床病理 B 细胞慢性淋巴增殖性疾病（B-CLPD）。这两种疾病都具有特征性的免疫表型和分子特征。两种 B-CLPD 同时存在的情况可能比以前认为的更为常见，但复合 HCL 和 CLL 很少有文献记载。本文报告了一例病例，其形态学与广泛的免疫表型分析相结合，并结合最近描述的 HCL 相关 BRAF V600E 突变，能够快速诊断为复合 HCL 和 CLL，从而选择适当的治疗方法。该病例强调了多学科方法在诊断双克隆 B-CLPD 中的重要性。
